寒性和热性方药应用法虚寒证、虚热证模型：
Cold and heat medicine used on the model of asthenia cold and asthenia hot disease:
寒证多由外感阴寒之邪，或内伤久病，阳气耗伤，阴邪内盛所致，表现为阳气温煦不足之象。热证多由外感火热之邪，或七情化火，或饮食不节，积蓄为热，或阴虚阳亢所致，表现为热盛阴伤之象。寒热证的实质研究发现其与机体交感－－肾上腺髓质系统功能，甲状腺功能，能量代谢，中枢神经递质等的改变有较肯定的关系，但虚热证与实热证、虚寒证与寒实证的病理差异尚未揭示。
The cold disease is caused by yin-cold evil from exogenous pathogenic factor, or the internal injury disease,yangqi consumes wound, the yin evil inside the prosperous with the result that, express yangqi warm shortage. The hot disease is caused by fire-heat evil from exogenous pathogenic factor, or seven modes of emotions turn fire, or food not stanza, saving is hot, or asthenic yin causing predominant yang with the result that, express excessive heat and yin injured. The substance research of cold and hot disease discovers it to hand over the feeling-marrow system of the-adrenal glands function with machine body, thyroid gland function, energy metabolism, the central nervous system passes quality etc. of the change have a more affirmative relation, but the pathologic difference of asthenic fever and sthenic fever, asthenia cold and sthenia cold haven't announced to public.
1．模型简述：临床过服寒性、热性方药患者可致体质改变而出现虚寒证、虚热证。中医传统临床上，自朱丹溪提倡“滋阴降火”学说，后人有片面理解者，造成黄柏和知母的滥用。《本草纲目》：“近时虚损及纵欲求嗣之人，用补阴药往往以此二味（作者注：指黄柏，知母）为君，日日服饵，降令太过，脾胃受伤，真阳暗损，精气不暖，致生他病。”《内科摘要》：“辄用黄柏、知母之类，反伤胃中生气，害人多矣。”其蔽至明末尚未止息。
Model brief description: Clinical lead to take cold, heat medicine sufferer can with the result that physical endowment change but appear asthenia cold, asthenic fever.  In Chinese medicine tradition clinical, since promote " nourishing yin to lessen fire " theory from Zhu Danxi, the posterity contain unilateral comprehension, resulting in Amur Cork-tree and Common Anemarrhena Rhizome 's abuse. 《Chinese Herbal Materia Medica 》:"The person who has consumptive disease and damages to indulge in sex to beg a son, used invigorating yin medicine usually with this two kinds(the author note:Point Amur Cork-tree and Common Anemarrhena Rhizome) as principal drug, take every day, decline excess, the appetite gets hurt, genuine YANG damage implicitly , the vitality isn't warm, with the result that has other disease.” 《Medicine summary》:"Just uses the kind of Amur Cork-tree and Common Anemarrhena Rhizome, then damage gastric qi, harm many person.”  Its disadvantage didn't yet end until Ming Dynasty.

华译网北京翻译公司翻译过大量有关寒性和热性方药应用法虚寒证、虚热证模型的文件资料,Beijing Chinese Translation Service Company has translated many technical documents about Cold and heat medicine used on the model of asthenia cold and asthenia hot disease
2．制作方法：雌性大鼠，体重180g～220g。热证用温热药附子∶肉桂∶干姜以1:1:1比例作成水煎剂，灌喂。用药量约20g/kgbw/d，用药天数14d。寒证用寒凉药知母∶石膏∶黄柏∶龙胆草以1.5:2:1:1.2比例做成水煎剂，灌喂。用药量约20g/kgbw/d，用药天数21d。
Product method:  The pantheress big rat, weight 180g-220g.  The hot disease uses thermy and heat medicine Prepared Common Monkshood Daughter Root∶Cassia Bark ∶Zingiber with 1:1:1 comparisons make a water fried, infusing to feed.  Use amount of medicine about the 20 gs/kgbw/d, use a medicine number 14d.  Cold symptom uses the cold and cool medicine Common Anemarrhena Rhizome ∶ gypsum ∶Amur Cork-tree ∶Radix Gentianae with 1.5:2:1:1.2 comparisons make into a water fried, infusing to feed. Use amount of medicine about the 20 gs/kgbw/d, use a medicine number 21d.
3．模型特点和应用范围：寒证：动物安静少动，蜷缩，畏寒，腹泻，行动迟缓，目光无神欲闭，自主活动减少，心率减慢，尿量增多，氧耗量降低，基础体温降低。基础痛阈、电针后痛阈、惊厥痛阈升高等。热证：心率加快，体重降低，竖毛，活动增加或少动，精神萎靡，饮水量增加，尿量略少，氧耗量增加。电针后痛阈、惊厥痛阈降低。热性中药可使寒证动物基础痛阈、电针后痛阈、惊厥痛阈大幅度下降。寒性中药使热证动物基础痛阈、电针后痛阈、惊厥痛阈明显升高。
Model characteristics and application:  Cold symptom:The animal calmness and little to move, scrunch, fear cold, diarrhea, activity dilatoriness, the dull-looking desire shuts, independent ctivity reduce, the heart rate reduces slowly, wetting quantity to increase, the oxygen consumes quantity to lower, the basal body temperature lowers.  The foundation pain threshold , the electric needle empress pain threshold , convulsion pain threshold goes up etc..  Hot symptom:Heart rate speed, the weight lowers, hair raise up, activity increment or little move, dispirited , the drinking measures increment, wetting quantity slightly little, the oxygen consumes quantity to increase.  The electric needle empress pain threshold , convulsion pain threshold lowers.  The hot Chinese herbal medicine can make cold symptom animal foundation pain threshold , the electric needle empress pain threshold and convulsion pain threshold is significant to descend.  The cold Chinese herbal medicine makes the hot symptom animal foundation pain threshold , the electric needle empress pain threshold and convulsion pain threshold go up obviously.