古代中医动物实验：古代中医动物实验甚少，简单地可分为两类：
Animal experiment of traditional Chinese medicine in ancient times: Animal experiment of traditional Chinese medicine in ancient times were few, simply divided into two kinds:
一类是对动物治病本能的观察应用。最早见于《吴普本草》，载駏驉食庵闾（草字头）神仙，遂以之为长寿药。汉华佗发现水獭食紫草解鱼蟹毒。东晋《抱朴子?内篇》载韩氏以地黄苗喂五十老马，生三驹，又一百三十岁乃死。《异苑?卷三》：“昔有田父耕地，值见伤蛇在焉。有一蛇衔草著疮上，经日，伤蛇走。田父取其草余叶以治疮，皆验。本不知草名，因以蛇衔为名。”
One kind is the application of the observation on the instinct of animal treat disease. Most early sees is in 《Wu Pu book on Chinese medicine》, and it said that after eating Artemisia keiskeana a mule became a deity, and then Artemisia keiskeana started to use as longevity medicine.In Han Dynasty, Hua tuo found that after eating Arnebia Root, otter drived out poison of fish and crab.In Eastern Jin Dynasty,《Bao pu zi ? nei pian》said that a surname Han’s person used Rehmannia Root to feed a horse of fifty years old, and then the horse gave birth to three Ma Ju, and afer one hundred and thirty years it died.《Yi yuan?volume 3》：“Before a farmer saw an injured snake when he planted crops.Another snake bit grass and put it on the wound, then one day, the injured snake crawled away. The farmer used the left grass to treat wound, and all cured.Because of unknowning the name of this grass, so the farmer called it Delphinium anthriscifolium.”
一类是对动物施加某种人为因素后的观察。最早见于《国语》记述婯姬以含乌头的肉饲狗以验其毒。《论衡?道虚》：“致生息之物密器之中，覆盖其口，漆涂其隙，中外气绝，息不得泄，有倾死也。”唐《疑狱集》载三国吴末张举以猪试验鉴别人烧死与死后焚尸，发现前者口中有灰，后者口中无灰。南北朝陈延之《小品方》载以动物判断井中有无毒气：“凡五月六月，井中及深冢中皆有伏气，入中令人郁闷杀人。如其必须入中者，先以鸡鸭杂鸟毛投之，直下至底，则无伏气；毛若徘徊不下，则有毒气也。亦可内生六畜等置中，若有毒，其物即死。”《本草拾遗》记载有：“赤铜屑主伤折，能焊人骨及六畜有损者，取细研酒中服之，直入骨损处。六畜死后，取骨视之，犹有焊痕，可验。”
One kind is the observation which is to the animal to exert a certain and artificial factor behind. Most early sees is in 《Guo yu》,and it said that Li ji used the meat containing aconite root to feed a dog to test its poison.《Lun heng ? dao xu》said that put the living in a airtight machine, covers it, the paint spreadsits crack, center the external Qi certainly, the rest dosen’t have torelease, has leans dies. ” In Tang Dynasty, 《Yi yu ji》 said that in Three Kingdoms Wu’s end Zhang ju distinguished the person die with burns and burn the corpse after die by the pig experiment, and discovered in former mouth has the ash, in latter mouth has no ash.  In Southern and Northern Dynasties 《Xiao pin fang》, which Chen yanzhi wrote, said that people used  the animal to judge poison gas in the well: "Every in May and June, in the well and the deep tomb all has Fu Qi, enters will makes people melancholy and kills people.  If must enter, first throws it by the chicken and duck mixed bird woolunder, is straight to the bottom, then no Fu Qi. The wool if cannot pace back and forth, then has the poison gas.  Also may in live livestocks and so on to set, if is virulent, its thing namely dies. ” 《Book on Chinese medicine Appropriates lost articles records》 has:"The red copper crumbs main wound booklet, can weld the person bone and livestocks has damaging, takes thin grinds in the liquor clothing it,straight enters bone damaging place.  After livestocks dies, takes the bone to regard it, welds the mark still had, may examine. ”

华译网北京翻译公司翻译过大量有关古代中医动物实验的文件资料,Beijing Chinese Translation Service Company has translated many technical documents about Animal experiment of traditional Chinese medicine in ancient times

（二）近、现代的中医动物（模型）实验（1840～1948）：
Traditional Chinese medicine animal (model) tests in modern times and age (1840～1948):
近代中医科研方法开始受西医动物实验的影响。张山雷（1872～1934）为验证中风与脑的关系，“尝以两兔，用针锥伤其脑，以试验此说是否可信。一则伤其前脑，而即已僵仆不动，然自能饮食，越十余日不死。一则伤其后脑，而时时奔走，遇物碍之则仆，而不知饮食，数日饿毙。”
The modern Chinese medicine research method starts being subjected to the influence of the medical doctor animal experiment.  Zhang Shanlei (1872 - 1934) wanted to confirm the relation between stroke and the brain, "tastes by two rabbits, with needle wound its brain, experiments this to say whether credibly.  A piece of wound its procerebrum, but namely has been stiff and motionless, however can diet itself, more ten days not die.  A piece of wound its cerebellum, but runs at times, meets the thing to obstruct then tumbles, but does not know the diet, several days later hungrily executes. ”
现代中医动物（模型）实验的发展首先开始于中药药理研究。1923年陈克恢与Schmidt、Read等着手研究中药当归和麻黄，次年，他们3人联名发表论文，报导用国产当归粗制浸膏作动物实验的结果，证明对(子宫、小肠、动脉血管等)平滑肌有兴奋作用。
The development of the modern Chinese medicine animal (model) tests first starts in the Chinese native medicine pharmacology research. In 1923, Chen Kehui, Schmidt, Read and so on began to study the Chinese native medicine Chinese Angelica and Ephedra. Next year, they jointly published the paper, reported the rough extractum of the domestically produced Chinese angelica did the animal experimentation, and proved to (womb, small intestine, artery blood vessel and so on) smooth muscle had the excited function.