会议名称(英文)： The Myelin Gordon Research Conference
所属学科： 病原生物学,生理学与病理学
开始日期： 2014-03-23
结束日期： 2014-03-28
所在国家： 美国
所在城市： 美国
具体地点： Ventura, CA
主办单位： Gordon Research Conference
协办单位：
承办单位：
议题：
[ 组织结构 ] 会议主席：
组织委员会主席：
程序委员会主席：
会议嘉宾： 姓名 职务 简介 演讲题目
[ 重要日期 ] 参会报名截止日期： 2014-02-23
[ 会务组联系方式 ] 联系人： Gordon Research Conference
联系电话： 401-783-7644
传真： 401-783-7644
E-MAIL：
通讯地址： 512 Liberty Lane West Kingston, RI 02892 USA
邮政编码：
会议注册费：
会议网站： http://www.grc.org/programs.aspx?year=2014&program=myelin
会议背景介绍： Our knowledge of the biology, physiology and pathology of myelinating cells in the central and peripheral nervous system is growing rapidly. The 2014 Myelin Gordon Conference will reflect the dynamic expansion in this field of neuroscience by bringing together researchers who are at the cutting edge of myelin biology to discuss the latest and most significant progress in the field. The emphasis of this conference will be on the relationships between myelin development, disease and regeneration, and will highlight basic cellular and molecular mechanisms of significant clinical relevance. Tentative topics include the biology of oligodendrocyte and Schwann cell progenitors, stem cells, inducible pluripotential stem cells, cytoskeleton of myelinating glia, myelin and axonal integrity, physiology of myelinating glia, ER stress and myelination, myelin regeneration and repair, developmental white matter injury, adult myelinogenesis, and the role of social and cognitive experience in myelination. We will make a special effort to invite young investigators as speakers. Senior investigators, who are leaders in the field, will serve as session chairs to ensure a lively discussion of topics. We particularly encourage members of under-represented minority groups to attend. All attendees will contribute either an oral or a poster presentation, and we expect to select some of the posters for short talks.
This conference will be held in conjunction with the Myelin Gordon Research Seminar, which will focus on myelin development and disease. This is the second year for a Myelin GRS, after a very successful first year in 2012. The Myelin GRS provides an opportunity for the next generation of myelin investigators to meet and exchange ideas in a more informal setting. This will foster presentations of current and cutting-edge research, and encourage collaboration among young scientists.
SUNDAY
4:00 pm - 8:00 pm Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Therapeutic Approaches to Remyelination
7:40 pm - 7:50 pm Discussion Leader: Bruce Trapp (Cleveland Clinic)
"Introduction"
7:50 pm - 8:20 pm Brenda Banwell (Children's Hospital Philadelphia)
"A 3D view of myelin biology in pediatric MS: demyelination, remyelination and primary myelination in the inflamed brain"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Steve Goldman (University of Rochester)
"Human glial progenitor-cell based treatment and modeling of myelin disease"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Dwight Bergles (Johns Hopkins University, Baltimore)
"Regulation of oligodendrocyte progenitors through AMPA receptor signaling"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Progenitor Self-renewal, Differentiation and Death
9:00 am - 9:05 am Discussion Leader: Jim Goldman (Columbia University, New York)
"Introduction"
9:05 am - 9:35 am Diego Cadavid (Rutgers University, New Jersey)
"The Clinical Trials have arrived: how are we going to measure remyelination in the living human CNS?"
9:35 am - 9:45 am Discussion
9:45 am - 10:15 am Steve Fancy (University of California, San Francisco)
"Parallel states of pathological Wnt signaling in colon cancer and non-genetic human white matter injury"
10:15 am - 10:25 am Discussion
10:25 am Coffee Break
11:00 am - 11:25 am Fraser Sim (University of Buffalo, SUNY)
"Muscarinic M3R regulation of human oligodendrocyte progenitor differentiation"
11:25 am - 11:35 am Discussion
11:35 am - 12:00 pm Margot Mayer-Proschel (University of Rochester)
"Impact of Latent human herpesvirus 6 infections on myelination"
12:00 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm Paul Tesar (Case Western Reserve University, Cleveland)
"In vitro generated OPCs provide a platform for discovery of myelin therapeutics"
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Signaling Pathways Regulating Myelination in Development and Injury
Discussion Leader: Terri Wood (Rutgers Biomedical & Health Sciences, Newark)
7:30 pm - 7:50 pm Carmen Birchmeier (Max Delbruck Center for Molecular Medicine, Berlin, Germany)
"A MAPK gain-of-function mutation in mice overrides the mechanisms that terminate myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Haesun Kim (Rutgers Biomedical & Health Sciences, Newark)
"MAPKs and myelin degeneration"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Joel Levine (SUNY, Stony Brook)
"Wnt signaling, OPCs and formation of the glial scar"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Wendy Macklin (University of Colorado School of Medicine, Denver)
"Role of mTOR in myelination"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Ben Deneen (Baylor College of Medicine)
"The Daam2 pathway: A hub for Wnt signaling during developmental and regenerative myelination"
9:25 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 am Breakfast
8:30 am Group Photo
9:00 am - 12:30 pm Cytoskeleton Control of Myelination
9:00 am - 9:05 am Discussion Leader: Ben Barres (Stanford University)
"Introduction"
9:05 am - 9:30 am Brad Zuchero (Stanford University)
"Actin assembly and disassembly power myelin wrapping and compaction"
9:30 am - 9:40 am Discussion
9:40 am - 10:05 am Cristina Fernandez-Valle (University of Central Florida)
"The Actin-binding protein, Cofilin, is essential for formation of stable Schwann cell-axon contacts and myelination"
10:05 am - 10:15 am Discussion
10:15 am Coffee Break
10:45 am - 11:10 am Elior Peles (Weizmann Institute)
"Regulation of actin polymerization in myelinating glia"
11:10 am - 11:20 am Discussion
11:20 am - 11:45 am Hauke Werner (Max Planck Institute, G?ttingen, Germany)
"Impaired integrity of CNS myelin lacking cytoskeletal septin filaments"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Schanila Nawaz (Max Planck Institute, G?ttingen, Germany)
"The role of the actin cytoskeleton in myelin sheath formation in oligodendrocytes"
12:20 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Endoplasmic Reticulum Stress and Myelination
7:30 pm - 7:35 pm Discussion Leader: Lawrence Wrabetz (SUNY at Buffalo)
"Introduction"
7:35 pm - 7:50 pm Hyung Don Ryoo (New York University)
"Unfolded Protein Response in Drosophila"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:15 pm Kelly Monk (Washington University, St Louis)
"Mutation of sec63 in zebrafish causes ER stress and myelin defects"
8:15 pm - 8:25 pm Discussion
8:25 pm - 8:45 pm Maurizio D'Antonio (San Raffaele Scientific Institute, Milan, Italy)
"Modulating proteostasis as a therapeutic strategy in hereditary neuropathies"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Brian Popko (University of Chicago)
"The integrated stress response provides protection against inflammatory CNS demyelination"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Axonal Signaling and Remyelination
9:00 am - 9:10 am Discussion Leader: David Attwell (University College, London)
9:10 am - 9:35 am David Lyons (University of Edinburgh, UK)
"Synaptic vesicle release regulates myelin sheath growth along CNS axons in vivo"
9:35 am - 9:45 am Discussion
9:45 am - 10:10 am Ragnhildur Thora Karadottir (Cambridge, UK)
"How neuronal activity regulates myelination and remyelination"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:15 am Nicola Hamilton (University College London, UK)
"Axon-oligodendrocyte signalling in ischaemia"
11:15 am - 11:25 am Discussion
11:25 am - 11:45 am Maria Kukley (University of Tübingen, Germany)
"Axonal signalling to Schwann cells"
11:45 am - 11:55 am Discussion
11:55 am - 12:20 pm Ruth Stassart (Max Planck Institute, G?ttingen, Germany)
"Schwann cell neuregulin-1 is an endogenous factor for myelin repair"
12:20 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Metabolic Support of Myelinated Axons
Discussion Leader: Klaus-Armin Nave (Max Planck Institute, G?ttingen, Germany)
7:30 pm - 7:50 pm Aiman Saab (University of Zurich, Switzerland)
"Oligodendroglial NMDA receptors regulating axonal energy metabolism"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:10 pm Jeff Rothstein (Johns Hopkins University)
"Oligodendroglia metabolic support of CNS neurons and its dysfunction in neurodegeneration"
8:10 pm - 8:15 pm Discussion
8:15 pm - 8:35 pm Nancy Ratner (Cincinnati Children's Hospital)
"Oligodendroyctes Regulate the BBB through NF1/Ras signaling"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:05 pm Jeff Milbrandt (Washington University, St Louis)
"Glial Metabolism and Axonal Stability"
9:05 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm Bruce Ransom (University of Washington, Seattle)
"Energy metabolism of CNS and PNS axons: the role(s) of glial glycogen"
9:25 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 am Breakfast
8:30 am - 9:00 am Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pm Human Fetal and Neonatal Myelin Development and Injury
9:00 am - 9:10 am Discussion Leader: David Rowitch (University of California, San Francisco)
9:10 am - 9:30 am Arnold Kriegstein (University of California, San Francisco)
"Oligodendrocyte precursor cells in human cortical development"
9:30 am - 9:40 am Discussion
9:40 am - 10:00 am Pierre Gressens (INSERM, Paris, France; Centre for the Developing Brain, KCL, London, UK)
"Mechanisms of inflammation-induced blockade of perinatal oligodendrocyte maturation blockade"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:00 am Jim Barkovich (University of California, San Francisco)
"Use of MRI in assessment of Developmental Myelination and Preterm Neonatal White Matter Injury"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 am Steven Miller (The Hospital for Sick Children and the University of Toronto)
"White matter development in the preterm neonate: the importance of the everyday"
11:30 am - 11:40 am Discussion
11:40 am - 11:55 am Tracy Yuen (University of California, San Francisco)
"Oligodendrocyte HIF function synchronizes postnatal myelination and white matter angiogenesis"
11:55 am - 12:05 pm Discussion
12:05 pm - 12:20 pm Joey Scafidi (Children's National Medical Center, Washington, DC)
"Recovery of premature brain injury using epidermal growth factor"
12:20 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Myelin Plasticity
Discussion Leader: Patrizia Casaccia (Mount Sinai School of Medicine)
7:30 pm - 7:40 pm Sandra Goebbels (Max Planck Institute, Gottingen, Germany)
"Myelin and white matter changes in aged mice"
7:40 pm - 7:45 pm Discussion
7:45 pm - 7:55 pm Cassandra Sampaio-Baptista (FMRIB Centre, University of Oxford)
"Motor skill learning induces changes in white matter microstructure and myelination"
7:55 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Po Lu (UCLA, Los Angeles, CA)
"Age-related Myelin Breakdown and Cognitive Impairment"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Philip Horner (University of Washington, Seattle)
"Internodal Length plasticity"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Mikael Simons (Max Planck Institute, G?ttingen, Germany)
"From the mechanisms of wrapping to the plasticity of myelin growth in the CNS"
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 am Breakfast
9:00 am Departure
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Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number 13NS086113. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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