会议名称(英文)： The 2014 Gordon Research Conference on "Regulated Proteolysis of Cell Surface Proteins"
所属学科： 生物物理学、生物化学及分子生物学,细胞生物学,生物医学工程学
开始日期： 2014-03-30
结束日期： 2014-04-04
所在国家： 美国
所在城市： 美国
具体地点： Ventura, CA
主办单位： Gordon Research Conference
协办单位：
承办单位：
[ 重要日期 ] 参会报名截止日期： 2014-03-02
[ 会务组联系方式 ] 联系人： Gordon Research Conference
联系电话： 401-783-7644
传真： 401-783-7644
E-MAIL：
通讯地址： 512 Liberty Lane West Kingston, RI 02892 USA
邮政编码：
会议注册费：
会议网站： http://www.grc.org/programs.aspx?year=2014&program=regulprot
会议背景介绍： Regulated proteolytic release of proteins from the membrane provides cells with information essential for controlling cell fate specification, maintaining organelle homeostasis, and sustaining tissue-specific functions. Genetic dysregulation of membrane proteolysis underlies many pathologies including Alzheimer’s disease, Parkinson’s disease, allergies, obesity, cardiac hypertrophy, inflammation, cancer and autoimmune diseases. Some of the world’s deadliest pathogens also rely upon these proteolytic cascades to infect hosts, causing diseases including malaria, tuberculosis, cholera and hepatitis C virus infection. Thus many members of the sheddase and intramembrane protease families are attractive targets for potential therapeutic intervention in dozens of diseases. Key sheddases include members of the A Disintegrin And Metalloproteinase (ADAM) family, meprins, and the aspartyl proteases beta-secretase (BACE1) and its homolog BACE2. Upon release of ectodomains by sheddases, the membrane-bound remnants are often cleaved by membrane-embedded proteases, which include the presenilin-containing gamma-secretases, signal peptide peptidases, and S2P families. These proteases contain multiple transmembrane domains, and their active sites reside within the boundaries of the lipid bilayer. Proteolysis within the transmembrane region of the substrate leads to release of the cytoplasmic domain, which in some cases can translocate to the nucleus and regulate transcription. Rhomboid intramembrane proteases release factors to the outside of the cell, often regulating cell signaling or adhesion. Focusing efforts on these various membrane proteolytic reactions as master regulators that impact major physiological and pathologic conditions, this meeting will bring together experts from diverse disciplines to discuss frontier projects, emerging experimental strategies and most recent advancement in understanding sheddase and intramembrane protease activities in health, disease, and therapy.
The chairs have provided a flyer for use in advertising the meeting. Click here to download the file (PDF format).
SUNDAY
4:00 pm - 8:00 pm Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Advancing our Understanding of ADAMs and iCLiPs Networks and Molecular Mechanisms
Discussion Leader: Marcia Moss (BioZyme, Inc.)
7:40 pm - 8:20 pm Keynote Lecture: Michael Wolfe (Harvard University)
"γ-Secretase and the mechanism of Alzheimer's disease"
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:10 pm Keynote Lecture: Paul Saftig (University of Kiel)
9:10 pm - 9:20 pm Discussion
9:30pm - 10:30 pm Opening Reception
MONDAY
7:30 am - 8:30 am Breakfast
8:30 am Group Photo
9:00 am - 12:30 pm Roles of ADAMs and iCLiPs in Development and Beyond
Discussion Leader: Matthew Freeman (University of Oxford)
9:00 am - 9:30 am Carl Blobel (Hospital for Special Surgery)
"iRhoms: Key regulators of ADAM17/EGFR and ADAM17/TNF signaling"
9:30 am - 9:45 am Discussion
9:45 am Coffee Break
10:15 am - 10:45 am Matthew Freeman (University of Oxford)
"The rhomboid-like family in mammals"
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am Walter Stoecker (Johannes Gutenberg Universitaet)
"Ovastacin and Fetuin-B: Gate keepers regulating sperm/egg fusion in mammals"
11:30 am - 11:45 am Discussion
11:45 am - 11:55 am TBA (Short talk)
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm TBA (Short talk)
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm TBA (Short talk)
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm ADAM- and iCLiP-Dependent Signaling Pathways
Discussion Leader: Stefan Rose-John (Christian-Albrechts-Universit?t zu Kiel)
7:30 pm - 8:00 pm Rama Khokha (University of Toronto)
"Timp influence on ADAM-dependent signaling"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Agnes No?l (University of Liege)
"Membrane type-4 MMP and its cell membrane landscape for outside-in signaling regulation"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Stefan Rose-John (Christian-Albrechts-Universit?t zu Kiel)
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Structural Biology of iCLiPs and Sheddases
Discussion Leader: Charles (Chuck) Sanders (Vanderbilt University)
9:00 am - 9:30 am Sin Urban (Howard Hughes Medical Institute)
"The implications of catalyzing proteolysis inside the membrane"
9:30 am - 9:45 am Discussion
9:45 am Coffee Break
10:15 am - 10:45 am Ana-Nicoleta Bondar (Freie Universit?t Berlin)
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am Joanne Lemieux (University of Alberta)
"Structural insight into regulation of rhomboid protease activity"
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Charles (Chuck) Sanders (Vanderbilt University)
"Structural Control of C99 Cleavage by Membrane Composition"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm iCLiP and Sheddase Modulators and Drug Discovery
Discussion Leader: Bart De-Strooper (VIB Center for the Biology of Disease)
7:30 pm - 8:00 pm Bart De-Strooper (VIB Center for the Biology of Disease)
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Harald Steiner (German Center for Neurodegenerative Diseases (DZNE))
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:10 pm TBA (Short talk)
9:10 pm - 9:15 pm Discussion
9:15 pm - 9:25 pm TBA (Short talk)
9:25 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm iCLiP and Sheddase Substrate Identification
Discussion Leader: Stefan Lichtenthaler (German Center for Neurodegenerative Diseases (DZNE))
9:00 am - 9:30 am Stefan Lichtenthaler (German Center for Neurodegenerative Diseases (DZNE))
"Proteomic RIP protease substrate identification in vitro and in vivo"
9:30 am - 9:45 am Discussion
9:45 am Coffee Break
10:15 am - 10:45 am Jim Wells (University of California at San Francisco (UCSF))
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am Maria Garcia-Parajo (ICFO - The Institute of Photonic Sciences)
11:30 am - 11:45 am Discussion
11:45 am - 12:15 pm Angus McQuibban (University of Toronto)
"Regulating the regulator; Rhomboid activity in mitochondrial health and death"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pm Regulation of Ectodomain Shedding and RIP
Discussion Leader: Christian Haass (Ludwig-Maximilians Universit?t München)
7:30 pm - 8:00 pm Wim Annaert (VIB Center for the Biology of Disease)
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Christian Haass (Ludwig-Maximilians Universit?t München)
"Regulated Intramembrane Proteolysis of TREM2 and its role in FTD and FTD-like syndrome"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Rudolph E. Tanzi (MGH/Harvard Medical School)
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm iCLiPs and Sheddases in Infectious Diseases
Discussion Leader: Mike Glickman (Memorial Sloan Kettering Cancer Center)
9:00 am - 9:30 am Jin Ye (UT Southwestern Medical Center)
"RIP of CREB3L1, an innate antiviral response and beyond"
9:30 am - 9:45 am Discussion
9:45 am Coffee Break
10:15 am - 10:45 am David Sibley (Washington University School of Medicine)
10:45 am - 11:00 am Discussion
11:00 am - 11:30 am Mike Glickman (Memorial Sloan Kettering Cancer Center)
11:30 am - 11:45 am Discussion
11:45 am - 11:55 am TBA (Short talk)
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm TBA (Short talk)
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm TBA (Short talk)
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm iCLiPs and Sheddases: from Bench toward Bedside
Discussion Leaders: Patrick May (Eli Lilly and Co.) & Bob Lazarus (Genentech Inc.)
7:30 pm - 8:00 pm Joaquin Arribas (Vall d'Hebron Institute of Oncology (VHIO))
"Ectodomain shedding during oncogene-induced senescence"
8:00 pm - 8:15 pm Discussion
8:15 pm - 8:45 pm Irit Sagi (Weizmann Institute of Science)
"Controlling ECM invasive diseases by attenuating membrane collagenase activity"
8:45 pm - 9:00 pm Discussion
9:00 pm - 9:30 pm Closing Remarks
FRIDAY
7:30 am - 8:30 am Breakfast
9:00 am Departure
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