会议名称(英文)： The Gordon Research Conference on Ligand Recognition and Molecular Gating
所属学科： 生物医学工程学
开始日期： 2014-03-23
结束日期： 2014-03-28
所在国家： 美国
所在城市： 美国
具体地点： Ventura, CA
主办单位： Gordon Research Conference
[ 组织结构 ] 会议主席：
组织委员会主席：
程序委员会主席：
会议嘉宾： 姓名 职务 简介 演讲题目
[ 重要日期 ] 参会报名截止日期： 2014-02-23
[ 会务组联系方式 ] 联系人： Gordon Research Conference
联系电话： 401-783-7644
传真： 401-783-7644
E-MAIL：
通讯地址： 512 Liberty Lane West Kingston, RI 02892 USA
邮政编码：
会议注册费：
会议网站： http://www.grc.org/programs.aspx?year=2014&program=ligand
会议背景介绍： The Gordon Research Conference on Ligand Recognition and Molecular Gating aims to share the latest knowledge on the functional mechanisms of ion channels, G-protein coupled receptors, and solute transporters. Specifically, the goal of the conference is to increase our understanding of how integral membrane proteins bind or recognize ligands (ions, small molecules, proteins), and how binding elicits conformational changes that lead to transport of the ligands across the membrane, the gating of channels, or the transmission of signals. There will be an emphasis on combining high-resolution structural data with information on dynamics to understand mechanisms.
SUNDAY
4:00 pm - 8:00 pm Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm GRCR activation
Discussion Leader: Reinhard Grisshammer (NIH)
7:35 pm - 8:00 pm Gebhard Schertler (Paul Scherrer Institut, Villigen, Switzerland)
"Structures of rhodopsin mutants that cause night blindness and retina degeneration"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Ron Dror (D.E. Shaw Research and Stanford University)
"Structural basis for allosteric modulation of GPCRs"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:20 pm Brian Kobilka (Stanford University)
"The dynamic process of GPCR activation: insights from the human β2 adrenoceptor"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
8:30 am Group Photo
9:00 am - 12:30 pm Cation Channel Gating
Discussion Leader: Crina Nimigean (Weill Cornell Medical College)
9:00 am - 9:25 am Kenton Swartz (NIH)
"Structure and gating mechanisms of ATP-activated P2X receptor channels"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Rachelle Gaudet (Harvard University)
"Structural insights into TRPV channel function in health and disease"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:30 am - 10:55 am Rick Aldrich (The University of Texas at Austin)
"SK channel gating and calmodulin"
10:55 am - 11:05 am Discussion
11:05 am - 11:15 am TBA (Poster talk
11:15 am - 11:20 am Discussion
11:20 am - 11:30 am TBA (Poster talk)
11:30 am - 11:35 am Discussion
11:35 am - 12:15 pm Eric Gouaux (Oregon Health & Science University)
"Mechanism of gating in ionotropic glutamate receptors"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Structure of GPCRs
Discussion Leader: Edmund Kunji (Medical Research Council, Cambridge, UK)
7:30 pm - 7:55 pm Martha Sommer (Institut für Medizinische Physik und Biophysik, Berlin, Germany)
"Arrestin-GPCR interactions"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Reinhard Grisshammer (NIH)
"The biology of neuropeptide receptors"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Chris Tate (Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK)
"Structures of agonist-bound GPCRs: understanding ligand efficacy and receptor activation"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Secondary active transporters
Discussion Leader: Olga Boudker (Weill Cornell Medical College)
9:00 am - 9:25 am Lucy Forrest (NIH)
"The role of sodium in coupled uptake by BetP"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Poul Nissen (Aarhus University, Denmark)
"New structures and functional insight of the neurotransmitter-sodium symporters"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:35 am - 11:05 am Joe Mindell (NIH)
"Conformational Changes in secondary active transporters"
11:05 am - 11:15 am Discussion
11:15 am - 11:25 am TBA (Poster talk)
11:25 am - 11:30 am Discussion
11:30 am - 11:40 am TBA (Poster talk)
11:40 am - 11:45 am Discussion
11:45 am - 12:15 pm Peter Henderson (University of Leeds, UK)
"Ligand recognition and molecular gating by the Mhp1 membrane transport protein"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Bacterial Specialties
Discussion Leader: Hassane Mchaourab (Vanderbilt University Medical Center)
7:30 pm - 7:55 pm Susan Buchanan (NIH)
"Structural insight into the biogenesis of β-barrel membrane proteins"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Katherine Henzler-Wildman (Washington University in St. Louis)
"Multidrug recognition by EmrE"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Bert Poolman (University of Groningen, The Netherlands)
"Protein traffic and solute translocation in microbial cells"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Spectroscopic and Microscopic methods
Discussion Leader: TBA
9:00 am - 9:25 am Baron Chanda (University of Wisconsin)
"Deconstructing allostery using fluorescent ligand binding measurements"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Enrica Bordignon (Freie Univerit?t, Berlin, Germany)
"EPR snapshots of spin-labeled ABC transporters during nucleotide cycle"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:35 am - 11:05 am Antoine van Oijen (University of Groningen, The Netherlands)
"Single-molecule fluorescence studies of membrane transporters"
11:05 am - 11:15 am Discussion
11:15 am - 11:25 am TBA (Poster talk)
11:25 am - 11:30 am Discussion
11:30 am - 11:40 am TBA (Poster talk)
11:40 am - 11:45 am Discussion
11:45 am - 12:15 pm Simon Scheuring (INSERM, Université de la Méditerannée, Marseille, France)
"Channel structure and interaction studied by Atomic Force Microscopy"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pm Channels
Discussion Leader: Rick Aldrich (The University of Texas at Austin)
7:30 pm - 7:55 pm Jo?o Morais Cabral (IBMC, Porto, Portugal)
"Structure and function of a potassium transporter"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Randy Stockbridge (Brandeis University)
"Dual topology architecture of fluoride-selective ion channels"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Raimund Dutzler (University of Zürich, Switzerland)
"Signal transduction at the domain interface of pentameric ligand gated ion channels"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm ABC transporters
Discussion Leader: Rachelle Gaudet (Harvard University)
9:00 am - 9:25 am Ina Urbatsch (Texas Tech University Health Sciences Center)
"Nucleotide-Binding Domain Association and Dissociation During the Hydrolysis Cycle of P-glycoprotein"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Hassane Mchaourab (Vanderbilt University Medical Center)
"Mechanistic diversity of ABC exporters"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:35 am - 11:05 am Robert Tampé (Johann Wolfgang Goethe-University, Frankfurt, Germany)
"Antigen recognition, translocation and loading orchestrated by a macromolecular machinery in adaptive immunity"
11:05 am - 11:15 am Discussion
11:15 am - 11:25 am TBA (Poster talk)
11:25 am - 11:30 am Discussion
11:30 am - 11:40 am TBA (Poster talk)
11:40 am - 11:45 am Discussion
11:45 am - 12:15 pm Kasper Locher (ETH, Zurich, Switzerland)
"Mechanism of cobalamin transport across the ABC transporter BtuCD-F"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Mitochondrial Transport Functions
Discussion Leader: Bert Poolman (University of Groningen, The Netherlands)
7:30 pm - 7:55 pm Edmund Kunji (Medical Research Council, Cambridge, UK)
"Molecular mechanism of transport and regulation of mitochondrial carriers"
7:55 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Carola Hunte (University of Freiburg, Germany)
"Ion translocation by sodium/proton antiporters"
8:35 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm John Walker (Medical Research Council, Cambridge, UK)
9:20 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 am Breakfast
9:00 am Departure
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