会议名称(中文)： 2014年细胞表面蛋白水解调控戈登会议
会议名称(英文)： The 2014 Gordon Research Conference on "Regulated Proteolysis of Cell Surface Proteins"
所属学科： 生物物理学、生物化学及分子生物学,细胞生物学,生物医学工程学
开始日期： 2014-03-30
结束日期： 2014-04-04
所在国家： 美国
所在城市： 美国
具体地点： Ventura, CA
主办单位： Gordon Research Conference
[ 重要日期 ]
参会报名截止日期： 2014-03-02
[ 会务组联系方式 ]
联系人： Gordon Research Conference
联系电话： 401-783-7644
传真： 401-783-7644
通讯地址： 512 Liberty Lane West Kingston, RI 02892 USA
会议网站： http://www.grc.org/programs.aspx?year=2014&program=regulprot
会议背景介绍： Regulated proteolytic release of proteins from the membrane provides cells with information essential for controlling cell fate specification, maintaining organelle homeostasis, and sustaining tissue-specific functions. Genetic dysregulation of membrane proteolysis underlies many pathologies including Alzheimer’s disease, Parkinson’s disease, allergies, obesity, cardiac hypertrophy, inflammation, cancer and autoimmune diseases. Some of the world’s deadliest pathogens also rely upon these proteolytic cascades to infect hosts, causing diseases including malaria, tuberculosis, cholera and hepatitis C virus infection. Thus many members of the sheddase and intramembrane protease families are attractive targets for potential therapeutic intervention in dozens of diseases. Key sheddases include members of the A Disintegrin And Metalloproteinase (ADAM) family, meprins, and the aspartyl proteases beta-secretase (BACE1) and its homolog BACE2. Upon release of ectodomains by sheddases, the membrane-bound remnants are often cleaved by membrane-embedded proteases, which include the presenilin-containing gamma-secretases, signal peptide peptidases, and S2P families. These proteases contain multiple transmembrane domains, and their active sites reside within the boundaries of the lipid bilayer. Proteolysis within the transmembrane region of the substrate leads to release of the cytoplasmic domain, which in some cases can translocate to the nucleus and regulate transcription. Rhomboid intramembrane proteases release factors to the outside of the cell, often regulating cell signaling or adhesion. Focusing efforts on these various membrane proteolytic reactions as master regulators that impact major physiological and pathologic conditions, this meeting will bring together experts from diverse disciplines to discuss frontier projects, emerging experimental strategies and most recent advancement in understanding sheddase and intramembrane protease activities in health, disease, and therapy.
The chairs have provided a flyer for use in advertising the meeting. Click here to download the file (PDF format).
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