教育经历:
1988年12月东南大学生物科学与医学工程系, 博士学位 1984年6月 东南大学 电子工程系, 硕士学位 1982年2月 东南大学电子工程系,工学学士
研究领域:
生物传感器和生物芯片 新一代DNA测序技术 生物信息学和健康信息技术
背景资料:
首批获教育部跨世纪优秀人才基金,国家自然科学基金优秀中青年基金,国家自然科学基金杰出人才基金,首批教育部“长江学者奖励计划”特聘教授。2002年国家自然科学基金创新研究群体项目负责人。曾获教育部科技进步二等奖3项、三等奖3项。指导了三篇全国优秀博士论文。中国电子学会生物医学电子学分会秘书长;国务院学位委员会第六届学科评议组成员,科技部863“十二五”生物医药领域前沿生物技术主题专家组成员。国际学术杂志“IEEE Transaction on Nanobioscience”、“IET nanobiotechnology”、《科学通报》、《仪器仪表学报》、《遗传学报》等学术刊物的编委等。多年来在新一代高通量DNA测序技术、新型生物芯片及其应用、以及生物信息分析等相关领域中取得了多项研究成果,在国际学术刊物上发表论文100多篇,获国家发明专利10多项,其中获美国发明专利1项。申请了国家发明专利20多项。 近十年的主要研究成果包括:提出并发展了硫代碱基切割合成测序、组合标记连接测序以及多重解码合成测序等新型的二代高通量低成本DNA测序技术,设计和研制了新一代高通量DNA测序的实验样机和测序芯片,发展了单分子多拷贝DNA测序文库的制备方法,开展了miRNA,ChIP-Seq,CNVs,微生物16s RNA,mRNA,模式生物基因组等测序,具备测序成本低、速度快、精确度高等优势。发展了甲基化检测芯片、双链DNA芯片、PCR产物微阵列芯片、Eppendorf管帽芯片( microarray-in-a-tube) 、荧光定量PCR微阵列芯片、免疫捕获细胞微阵列芯片等多种新型生物芯片技术,并应用于大量临床样本的检测。
获得荣誉:
2001年宝钢教学特等奖 2004年江苏省青年科学家奖 2007江苏省333高层次人才培养工程中青年首席科学家 2007获全国模范教师称号
主要论文列表:
(1) H.Wang, J.Li, H.Liu, Q.Liu, Q.Mei, Y.Wang, J.Zhu, N.He and Z.Lu,Label-free hybridization detection of a single nucleotide mismatch by immobilization of molecular beacons on an agarose film,Nucleic Acid Research.2002,30:e61× (2) P.Xiao, N.He,and Z.Lu, In situ synthesis of oligonucleotide arrays by using soft lithography. Nanotechnology.2002,13:756-762 (3) J.Ma, T.Zhou, W.Gu, X.Sun,and Z.Lu,Cluster analysis of the codon use frequency of MHC genes from different species,Biosystems.2002, 65:199-207 (4) P.Hou, M.Ji, C.Ge, J.Shen, S.Li, N.He and Z.Lu, Detection of methylation of human p16Ink4a gene 5’-CpG islands by electrochemical method coupled with linker-PCR, Nucleic Acids Research. 2003,31:e92 (5) C.Zhang, Y.Zhang, X.Wang, Z.Tang and Z.Lu,Hyper-rayleigh scattering of protein-modified gold nanoparticles, Analytical Biochemistry. 2003, 320:136-140 (6) C. Zhang, H. Liu, Z. Tang, N. He, and Z. Lu, Cell detection based on protein array using modified glass slides, Electrophoresis. 2003, 24:3279-3283 (7) T. Li, J. Wang, Y. Bai, X. Sun, and Z. Lu, A novel method for screening species-specific gDNA probes for species identification, Nucleic Acids Research. 2004, 32:e42 (8) W. Gu, T. Zhou, J. Ma, Xiao Sun, and Z. Lu. Analysis of synonymous codon usage in SARS coronavirus and other viruses in the nidovirales, Virus Research. 2004, 101: 155–161 (9) Y. Zhu, H. Zeng, J. Xie, L. Ba, X. Gao, and Z. Lu, Atomic Force Microscopy studies on DNA structural changes induced by vincristine sulfate and aspirin, Microscopy and Microanalysis. 2004, 10: 286-290 (10)M. Ji , P. Hou , S. Li , N. He and Z. Lu,Microarray-based method for genotyping of functional single nucleotide polymorphisms using dual-color fluorescence hybridization,Mutation Research. 2004, 548:97-105 (11)Q. Liu, Q. Zhou, Y. Bai, Q. Ge, and Z. Lu, Detection and analysis system for hybridization images of Lab-in-a-Tube microarray, Chinese Science Bulletin. 2005, 50: 2896-2900 (12)H. Liu, H. Wang, Z. Shi, H. Wang, C. Yang, S. Silke, W. Tan and Z. Lu, TaqMan probe array for quantitative detection of DNA targets, Nucleic Acids Research. 2006, 34: e4 (13)P. Hou, M. Ji, B. Yang, Z. Chen, J. Qiu, X. Shi, and Z. Lu, Quantitative Analysis of Promoter Hypermethylation in Multiple Genes in Osteosarcoma, Cancer. 2006, 106:1602-1609 (14)T. Zhou, X. Sun, Z. Lu, “Synonymous codon usage in environmental chlamydia UWE25 reflects an evolutional divergence from pathogenic chlamydiae ”GENE. 2006, 368:117-125 (15)P. Jiang, H. Wu, W. Wang, W. Ma, X. Sun, Z. Lu, MiPred: classification of real and pseudo microRNA precursors using random forest prediction model with combined features, Nucleic Acids Research. 2007, 35: W339-W344 (16)P. Jiang, H. Wu, J. Wei, F. Sang, X. Sun, and Z. Lu, RF-DYMHC: detecting the yeast meiotic recombination hotspots and coldspots by random forest model using gapped dinucleotide composition features, Nucleic Acids Research. 2007, 35: W47-W51
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