李毅 |
李毅
[个人简历]
北京大学生命科学学院教授, 北京大学生命科学学院博士生导师
fax : 86 - 10 - 6275-4427
tel : 86 - 10 - 6275-9690
北京市海淀区颐和园路5号，北京大学生命科学学院 , 北京 , 中国 , postcode：100871
科研领域描述
本实验室主要兴趣在于：
病毒与宿主的相互作用以及病毒对宿主发育的影响；
宿主对病毒基因的沉默以及病毒对宿主基因沉默的抑制；
抗呼肠孤病毒化合物的筛选及其抗病毒机制研究；
参与宿主抗病反应的细胞因子的结构和功能研究。
Research Fields：
Current projects focus on virus–host interactions and structural studies on host factors involved in virus-host interaction and plant defense against pathogens. These projects fall into several specific topics:
1. Interactions between host genes and genes from RDV and disease induction;
2. Virus induced gene silencing and silencing suppression;
3. Screening of antiviral compounds from medicinal plants and their mechanism against virus infection;
4. Structural studies on host factors involved in virus-host interaction and plant defense against pathogens.
代表性论文
Feng Zhou, Yingying Pu, Taiyuan Wei, Huijun Liu, Wulan Deng, Chunhong Wei, Biao Ding, Toshihiro Omura and Yi Li. , The P2 capsid Protein of the nonenveloped Rice Dwarf Phytoreovirus induces membrane fusion in insect host cells , PNAS , 2007 , 104:19547-19552.
Huijun Liu, Chunhong Wei, Yongwang Zhong, Yi Li. , Rice black-streaked dwarf virus outer capsid protein P10 has self-interactions and forms oligomeric complexes in solution , Virus Research , 2007 , 127:34-42
Feng Zhou, Gang Wu, Wulan Deng, Yingying Pu，Chunhong Wei and Yi Li , Interaction of rice dwarf virus outer capsid P8 protein with rice glycolate oxidase mediates relocalization of P8 , FEBS Letter , 2007 , 581:34-40.
Ming-Rui Duan, Jie Nan, Yu-He Liang, Peng Mao, Lu Lu, Lanfen Li, Chunhong Wei, Luhua Lai, Yi Li, and Xiao-Dong Su , DNA Binding Mechanism Revealed by High Resolution Crystal Structure of Arabidopsis thaliana WRKY1 Protein , Nucleic Acid Research , 2007 , 35 (4): 1145-1154
Huijun Liu, Chunhong Wei, Yongwang Zhong, Yi Li , Rice black-streaked dwarf virus minor core protein P8 is a nuclear dimeric protein and represses transcription in tobacco protoplasts , FEBS Letter , 2007 , 581:2534-2540
Shifeng Zhu, Mao Chen, Yi Li. , Interaction of the P2 protein of rice dwarf Phytoreovirus with ent-kaurene oxidase resulting in reducing GA content and this may further cause dwarf in RDV infected rice plants , Plant Physiology , 2005 , 139:1935-1945
Leister T., Dahlbeck D., Day, D., Li, Y., Staskwicz, B. , Molecular genetic evidence for the role of SGT1 in the intramolecular complementation of Bs2 protein activity in Nicotiana benthamiana , The Plant Cell , 2005 , 17:1268－1278
Xuesong Cao, Peng Zhou, Xiaoming Zhang, Shifeng Zhu, Xuehua Zhong, Qi Xiao, Biao Ding, Li Yi. , A RNA silencing suppressor from rice phytoreovirus , Journal of Virology , 2005 , 79:13018-13027 , Highlighted in the issue
Li Y, Bao Y, Wei C, et al, , Rice dwarf phytoreovirus segment S6-encoded nonstructural protein has a cell-to-cell movement function , Journal of Virology , 2004 , 78: 5382-5380. |
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