科研领域描述
缺血性脑卒中是危害人类生命健康的重大疾病。在全脑缺血或局部缺血的核心区，胞外谷氨酸浓度可达到100-300mM。谷氨酸的积累造成谷氨酸受体的过度激活，胞内钙离子超载，并引发神经元的凋亡及坏死。本实验室的兴趣在于利用电生理学和激光共聚焦成像技术、结合分子生物学等实验方法，研究脑缺血损伤过程中神经元钙稳态的调控机制、神经元与胶质细胞相互作用机制。另一方面，因冬眠动物达乌尔黄鼠具有耐受低温和低氧环境的特性，以及近期我们证实黄鼠能够一定程度抵抗心脏停跳导致的脑缺血损伤，本实验室希望从神经元及胶质细胞入手深入研究其缺血耐受的神经机制。
代表性论文
1. He JQ, Shi WK, Guo Y, Chai Z* , ERp57 modulates mitochondrial calcium uptake through the MCU , FEBS Lett , 2014 , 588: 2087-2094
2. Dong QP, He JQ, Chai Z* , Astrocytic Ca2+ waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia , Neurobiol Dis , 2013 , 58: 68-75
3. Cui J, Wang YF, Dong QP, Wu SM, Xiao XZ, Hu JY, Chai Z*, Zhang Y* , Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70 , J Neurosci , 2011 , 31: 16227-16240
4. Sun BN, Lv B, Dong QP, Wang SQ, Chai Z* , Watching moving images specifically promotes development of medial area of secondary visual cortex in rat , Dev Neurobiol , 2009 , 69: 558-567
5. Tang AH, Chai Z, Wang SQ* , Dark rearing alters the short-term synaptic plasticity in visual cortex , Neurosci Lett , 2007 , 206: 799-806
6. Zhou C, Tai C, Ye HH, Ren X, Chen JG, Wang, SQ, Chai Z* , Interleukin-1β downregulates the L-Type Ca2+ channel activity by depressing the expression of channel protein in cortical neurons , J Cell Physiol , 2006 , 206: 799-806.
7. Zhou C, Ye HH, Wang SQ, Chai Z* , Interleukin-1β regulation of N-type Ca2+ channels in cortical neurons , Neurosci Lett , 2006 , 403: 181-185
8. Fu Y, Zhang GQ, Hao XM, Wu CH, Chai Z, Wang SQ* , Temperature dependence and thermodynamic properties of Ca sparks in rat cardiomyocytes. , Biophys J , 2005 , 89: 2533-2541
9. Alheim K, Chai Z, Fantuzzi G, Hasanvan H, Di Santo E, Ghezzi P, Dinarello CA, Bartfai T* , Hyperresponsive febrile reactions to IL-1β in IL-1β deficient mice; comparison with cytokine mRNA and protein levels. , Proc Natl Acad Sci USA , 1997 , 94: 2681-2686
10. Chai Z, Gatti S, Toniatti C, Poli V, Bartfai T* , Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1β: a study on IL-6-deficient mice. , J Exp Med , 1996 , 183: 311-316 |
