科研领域描述
本实验室主要兴趣在于：
体细胞重编程
人胚胎干细胞定向分化
再生医学
Research Fields：
1. Cellular reprogramming
2. Directed differentiation of human embryonic stem cells
3. Regenerative medicine
代表性论文
1. Yu C, Liu Y, Miao Z, Yin M, Lu W, Lv Y, Ding M, Deng H. , Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors , Blood , 2010 , [Epub ahead of print]
2. Yang W, Wei W, Shi C, Zhu J, Ying W, Shen Y, Ye X, Fang L, Duo S, Che J, Shen H, Ding S, Deng H , Pluripotin combined with LIF greatly promotes the derivation of ES cell lines from refractory strains , Stem Cells , 2009 , 27(2):383-9.
3. Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H and Ding S , Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors , Cell Stem Cell , 2009 , 4(1):16-9.
4. Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H, Jiang W, Cai J, Liu M, Cui K, Qu X, Xiang T, Lu D, Chi X, Gao G, Ji W, Ding M, Deng H , Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts , Cell Stem Cell , 2008 , 3(6):587-90.
5. Zhao Y, Yin X, Qin H, Zhu F, Liu H, Yang W, Zhang Q, Xiang C, Hou P, Song Z, Liu Y, Yong J, Zhang P, Cai J, Liu M, Li H, Li Y, Qu X, Cui K, Zhang W, Xiang T, Wu Y, Zhao Y, Liu C, Yu C, Yuan K, Lou J, Ding M, Deng H , Two supporting factors greatly improve the efficiency of human iPSC generation , Cell Stem Cell , 2008 , 3(5):475-9.
6. Jiang W, Bai Z, Zhang D, Shi Y, Yong J, Chen S, Ding M, Deng H, , Differentiation of Mouse Nuclear Transfer Embryonic Stem Cells into Functional Pancreatic Beta Cells. , Diabetologia , 2008 , 51(9):1671-9
7. Zhang P, Li J, Wang C, Tan Z, Liu T, Chen L, Yong J, Jiang W, Sun X, Ding M, Deng H, , Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. , Blood , 2008 , 111(4): 1933-41.
8. Wang C, Faloon P, Tan Z, Lv Y. Zhang P, Deng H, Xiong J, , Mouse Lycat Controls the Development of Hematopoietic and Endothelial Lineages during in vitro ES Cell Differentiation. , Blood , 2007 , 110(10): 3601-9.
9. Cai J, Zhao Y, Ye F, Liu Y, Song Zhi, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M, Deng H, , Directed differentiation of human embryonic stem cells into functional hepatic cells. , Hepatology , 2007 , 45(5): 1229-1239.
10. Qin H, Yu T, Qing T, Liu Y, Zhao Y, Cai J, Li J, Song Z, Qu X, Zhou P, Wu J, Ding M, Deng H, , Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. , J Biol Chem , 2007 , 282(8): 5842-52.
11. Qin H, Yu T, Qing T, Liu Y, Zhao Y, Cai J, Li J, Song Z, Qu X, Zhou P, Wu J, Ding M, Deng H, , Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. , J Biol Chem , 2007 , 282(8): 5842-52.
12. Qing T, Liu H, Wei W, Ye X, Shen W, Zhang D, Song Z, Yang W, Ding M, Deng H , Mature oocytes derived from purified mouse fetal germ cells. , Human Reproduction , 2007 , 134(2):223-31.
13. Ren L, Gao G, Zhao D, Ding M, Luo J, Deng H, , Developmental stage related patterns of codon usage and genomic GC content: searching for evolutionary fingerprint by models of stem cell differentiation. , Genome Biol , 2007 , 12;8(3):R35
14. Zheng A, Yuan F, Li Y, Zhu F, Hou P, Li J, Song X, Ding M, Deng H, , Claudin-6 and Claudin-9 Function as Additional co-Receptors for Hepatitis C Virus. , J Virol , 2007 , 81(22): 12465-71.
15. Shi Y, Hou L, Tang F, Jiang W, Wang P, Ding M, Deng H, , Inducing Embryonic Stem Cells to Differentiate into Pancreatic Beta Cells by a Novel Three-Step Approach with Activin A and All-Trans Retinoic Acid. , Stem Cells , 2005 , 23(5): 656-62. 52.
16. Deng H, Unutmaz D, Kewalramani V, Littman D , Expression cloning of novel coreceptors utilized by the simion and human immunodeficency viruses , Nature , 1997 , 388:296-300.
17. Deng H, Liu R, Ellmeier W, Choe S, Untmaz D, Burkhart M, Marazio P, Marmon S, Sutton R., Hill C, Davis C, Peiper S, Schall T, Littman D, Landau N , Identification of a major co-receptor for primary isolates HIV-1 , Nature , 1996 , 381:661-666. |
