Research Description:
1. Cellular signal transduction and apoptosis. We focus on the signal pathways in innate immune system and inflammation related diseases.
2. The cloning and functional study of disease related genes. We are interested in the genes related to aging、inflammation and cancer.
3. Gene medicine and gene therapy. We are developing recombinant protein and peptide against tumor、inflammation and thrombus as well as gene therapy model.
代表性论文
1. Feng Liu, Su Wu, Hongwei Ren and Jun Gu , Klotho suppresses RIG-I mediated senescence-associated inflammation , Nature Cell Biology , 2011 , 13, 254–262
2. Zhiguo Sun, Hongwei Ren ,Yan Liu， Jessica L. Teeling and Jun Gu , Phosphorylation of RIG-I by casein kinase II inhibits its anti-viral response , J. Virology , 2011 , 85:1036-47
3. Lijuan Xu, Nengming Xiao, Feng Liu, Hongwei Ren and Jun Gu , Inhibition of RIG-I/MDA5 dependent antiviral response by gC1qR at mitochondria , Proc Natl Acad Sci U S A , 2009 , 106:1530-5
4. Wang J, Wu S, Jin X, Li M, Chen S, Teeling JL, Perry VH, Gu J , Retinoic Acid-Inducible Gene-I Mediates Late Phase Induction of TNF-{alpha} by Lipopolysaccharide , J Immunol , 2008 , Jun 15;180(12):8011-9
5. Yufei Zou, Yahui Chen, Yongqiang Jiang Jin Gao and Jun Gu , Targeting Matrix Metalloproteinases and endothelial cells with a fusion peptide against tumor , Cancer Res , 2007 , 67:7295-7300
6. He J, Chen S. and Gu J , Identification and characterization of Harobin, a novel fibrino(geno)lytic serine protease from a sea snake (Lapemis hardwickii) , FEBS Lett , 2007 , 581(16):2965-73
7. Ziqiang Yang, Wei Cheng, Lixin Hong, Shengcai Lin, Jiahuai Han, Huamin Zhou and Jun Gu , Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor-induced apoptosis of MCF-7 cells , Molecular Biology of the Cell , 2007 , 18: 4681-89.
8. Jiang YQ, Wang HR, Li HP, Hao HJ, ZhangYL and Gu J , Targeting of hepatoma cell and suppression of tumor growth by a novel 12mer peptide fused to superantigen TSST-1 , J. Mol Med , 2006 , 12, 81-87
9. Wei JX, Sun ZG, Chen QL and Gu J. , Serum deprivation induced apoptosis in macrophage is mediated by autocrine secretion of type I IFNs , Apoptosis , 2006 , 11(4):545-54
10. Jing Fu, Ziqiang Yang，Jinxue Wei,Jiahuai Han and Jun Gu. , NP60 nuclear protein regulates p38 MAPK activity. , J Cell Sci. , 2006 , 119(Pt 1):115-23.
11. Fu WX, Wei JX and Gu J. , MEF2C mediates the activation induced cell death (AICD) of macrophage. , Cell Res. , 2006 , 16, 559-565
12. He JY, Deng J, Zheng J and Gu J , A synergistic effect on the production of S-adenosyl-l-methionine in Pichia pastoris by knocking in of S-adenosyl-l-methionine synthase and knocking out of cystathionine-beta synthase , J Biotechnol , 2006 , 126(4), 519-527.
13. Xue-Dong Wang, Jian-Guo Tang, Xiao-lei Xie, Ji-Chun Yang, Shuai Li, Jian-Guo Ji and Jun Gu , A comprehensive study of optimal conditions for naked plasmid DNA transfer into skeletal muscle by electroporation. , J Gene Med , 2005 , 7:1235-1245
14. Liu BN, Tang JG, Ji JG, and Gu J , The expression of functional human parathyroid homone in a gene therapy model for osteoporosis , Cell Tissue Res , 2004 , 317, 57-63
15. Kegang Shang, Xiaoke wang, and Jun Gu , Differentiation of Embryonic Stem Cell to Astrocytes Visualized by Green Fluoresent Protein Fuchou Tang , Cellular and Molecular Neurobiology , 2002 , 22: 95-101
16. J.Sun, MT.LI, J.Han and J.Gu. , Sensitization of differentiated PC12 cells to apoptpsis by presenilin-2mediated by p38 , Biochem. Biophy. Res. Com. , 2001 , 287; 536-541, 2001
17. J.Gu et al.in International Human Genome Consortium , Initial sequencing and analysis of the human genome , Nature , 2001 , 409:860-921
18. W.Zhu, J.S.Downey, J.GU, F.D.Padova, H.Gram and J.Han , Regulation of TNF expression by multiple MAP kinase pathway , J. Immunology , 2000 , 164:6349-6358
