科研领域描述
主要有三个研究方向。首先植物激素对于植物发育的很多方面都很重要，而植物中也进化出了若干种机制来调节植物体内激素的水平，这些机制包括植物生长素的从头合成、降解以及与糖分子和氨基酸形成辍合物。我们实验室在分子和亚细胞水平研究植物激素的甲基化修饰与植物生长发育（包括叶片卷曲和种子萌发等）之间的调控关系，通过研究这种新的修饰方式可以帮助我们进一步理解植物激素的活性调控的复杂性，解决“激素多种调控方式是否参与其多种生物学功能”这一科学问题。我们同时还对植物的分枝的调控分子机理感兴趣，也正在通过功能缺失突变体研究一些基因和途径在这些发育过程中的作用。其次，我们对蛋白质降解途径在雌雄配子体以及胚胎发生发育过程中的作用感兴趣，目前正在通过反向遗传学的方法进行研究。其三，我们正在系统地对拟南芥转录因子基因进行功能鉴定。
代表性论文
1. Zhang Y., Wu R., Qin G., Chen Z., Gu H. and Qu L.-J. , Over-expression of WOX1 leads to defects in meristem development and polyamine homeostasis in Arabidopsis , Journal of Integrative Plant Biology , 2011 , 53: 493-506
2. Luo Y., Qin G., Zhang J., Liang Y., Song Y., Zhao M., Tsuge T., Aoyama T., Liu J., Gu H. and Qu L.-J. , D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis , The Plant Cell , 2011 , 23: 1352-1372
3. Ou B., Yin K., Liu S., Yang Y., Gu T., Hui J.M.W., Zhang L., Miao J., Kondou Y., Matsui M., Gu H. and Qu L.-J. , A high-through screening system for Arabidopsis transcription factors and its application to Med25-dependent transcriptional regulation , Molecular Plant , 2011 , 4: 546-555
4. Hou X., Li L., Peng Z., Wei B., Tang S., Ding M., Liu J., Zhang F., Zhao Y., Gu H., Qu L.-J. , A platform of high-density INDEL/CAPS markers for map-based cloning in Arabidopsis , The Plant Journal , 2010 , 63: 880-888
5. Qu L.-J., Li S., Xing S.H. , Methylation of phytohormones by the SABATH methyltransferases , Chinese Bulletins of Sciences , 2010 , 55(21): 2211-2218
6. Xing S., Miao J., Li S., Qin G., Tang S., Li H., Gu H., Qu L.-J. , Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis , Cell Research , 2010 , 20: 688-700
7. Guo Y., Qin G., Gu H., Qu L.-J. , HCA2, a Dof transcription factor gene, regulates interfascicular cambium formation and vascular tissue development in Arabidopsis , The Plant Cell , 2009 , 21: 3518-3534
8. Liu J., Qu L.-J. , Meiotic and mitotic cell cycle mutants involved in gametophyte development in Arabidopsis , Molecular Plant , 2008 , 1(4): 564-574
9. Li L., Qin G., Tsuge T., Hou X., Ding M., Aoyama T., Oka A., Chen Z., Gu H., Zhao Y., Qu L.-J. , SPOROCYTELESS modulates YUCCA expression to regulate the development of lateral organs in Arabidopsis , New Phytologist , 2008 , 179: 751-764
10. Liu J., Zhang Y., Qin G., Tsuge T., Sakaguchi N., Luo G., Sun K., Shi D., Aki S., Zheng N., Aoyama T., Oka A., Yang W., Umeda M., Xie Q., Gu H., Qu L.-J. , Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell cycle progression during Arabidopsis gametogenesis , The Plant Cell , 2008 , 20: 1538-1554
11. Li X., Qin G., Chen Z.L., Gu H., Qu L.-J. , A gain-of-function mutation of transcriptional factor PTL results in curly leaves, dwarfism and male sterility by affecting auxin homeostasis , Plant Molecular Biology , 2008 , 66: 315-327.
12. Li L., Hou X., Tsuge T., Ding M., Aoyama T., Oka A., Gu H., Zhao Y., Qu L.-J. , The possible action mechanisms of indole-3-acetic acid methyl ester in Arabidopsis , Plant Cell Reports , 2008 , 27: 575-584
13. Lin Z., Yin K., Wang X., Liu M., Chen Z., Gu H. and Qu L.-J. , Virus induced gene silencing of AtCDC5 results in accelerated cell death in Arabidopsis leaves , Plant Physiol. Biochem. , 2007 , 45: 87-94.
14. Lin Z., Yin K., Zhu D., Chen Z.L., Gu H. and Qu L.-J. , AtCDC5 regulates G2 to M transition of cell cycle and is critical for the function of Arabidopsis shoot apical meristems , Cell Research , 2007 , 17: 815-828
15. Qin G., Gu H., Ma L., Peng Y., Deng X.-W., Chen Z.L., and Qu L.-J. , Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll, carotenoid, and gibberellin biosynthesis , Cell Research , 2007 , 17: 471-482
16. Yang X.Y., Li J.G., Pei M., Gu H., Chen Z.L., Qu L.-J. , Over-expression of a flower-specific transcription factor gene AtMYB24 causes aberrant anther development , Plant Cell Reports , 2007 , 26: 219-228
17. Zhang X., Chen Y., Wang Z.-Y., Chen Z.L., Gu H., and Qu L.-J. , Constitutive expression of CIR1 (RVE2) affects several circadian-regulated process and seed germination in Arabidopsis , The Plant Journal , 2007 , 51: 512-525
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