本实验室主要兴趣在于：
病毒与宿主的相互作用以及病毒对宿主发育的影响；
宿主对病毒基因的沉默以及病毒对宿主基因沉默的抑制；
抗呼肠孤病毒化合物的筛选及其抗病毒机制研究；
参与宿主抗病反应的细胞因子的结构和功能研究。
Research Fields：
Current projects focus on virus–host interactions and structural studies on host factors involved in virus-host interaction and plant defense against pathogens. These projects fall into several specific topics:
1. Interactions between host genes and genes from RDV and disease induction;
2. Virus induced gene silencing and silencing suppression;
3. Screening of antiviral compounds from medicinal plants and their mechanism against virus infection;
4. Structural studies on host factors involved in virus-host interaction and plant defense against pathogens.
代表性论文
1. Du P., Wu J.G., Zhang J.Y., Zhao S.Q., Zheng H., Gao G., Wei L.P., Li Y. , Viral Infection Induces Expression of Novel Phased MicroRNAs from Conserved Cellular MicroRNA Precursors , PLoS Pathogens , 2011 , 7(8) e1002176
2. Ji X., Qian D., Wei C.H., Ye G.Y., Zhang Z.K., Wu Z.J., Xie L.H., Li Y. , Movement Protein Pns6 of Rice dwarf phytoreovirus Has Both ATPase and RNA Binding Activities , PLoS ONE , 2011 , 6(9): e24986
3. Pu Y.Y, Kikuchi A., Moriyasu Y., Tomaru M., Jin Y., Suga H., Hagiwara K., Akita F,. Shimizu T., Netsu O, Suzuki N, Uehara-Ichiki T, Sasaya T, Wei T.Y., Li Y., and Omura T. , Rice Dwarf Viruses with Dysfunctional Genomes Generated in Plants Are Filtered Out in Vector Insects: Implications for the Origin of the Virus , Journal of Virology , 2011 , 85:2975–2979.
4. Qian D., Jiang L., Lu L., Wei C.H., Li Y. , Biochemical and Structural Properties of Cyanases from Arabidopsis thaliana and Oryza sativa , PLoS ONE , 2011 , 6,e18300
5. Ren B., Guo Y.Y., Gao F., Zhou P., Meng Z., Wu F., Wei C.H., Li Y. , Multiple functions of Pns10 encoded by Rice dwarf virus Pns10 in suppressing systemic RNA silencing , Journal of Virology , 2010 , 84:12914－12923
6. Huijun Liu, Chunhong Wei, Yongwang Zhong, Yi Li , Rice black-streaked dwarf virus minor core protein P8 is a nuclear dimeric protein and represses transcription in tobacco protoplasts , FEBS Letter , 2007 , 581:2534-2540
7. Feng Zhou, Gang Wu, Wulan Deng, Yingying Pu，Chunhong Wei and Yi Li , Interaction of rice dwarf virus outer capsid P8 protein with rice glycolate oxidase mediates relocalization of P8 , FEBS Letter , 2007 , 581:34-40.
8. Feng Zhou, Yingying Pu, Taiyuan Wei, Huijun Liu, Wulan Deng, Chunhong Wei, Biao Ding, Toshihiro Omura and Yi Li. , The P2 capsid Protein of the nonenveloped Rice Dwarf Phytoreovirus induces membrane fusion in insect host cells , PNAS , 2007 , 104:19547-19552.
9. Huijun Liu, Chunhong Wei, Yongwang Zhong, Yi Li. , Rice black-streaked dwarf virus outer capsid protein P10 has self-interactions and forms oligomeric complexes in solution , Virus Research , 2007 , 127:34-42
10. Ming-Rui Duan, Jie Nan, Yu-He Liang, Peng Mao, Lu Lu, Lanfen Li, Chunhong Wei, Luhua Lai, Yi Li, and Xiao-Dong Su , DNA Binding Mechanism Revealed by High Resolution Crystal Structure of Arabidopsis thaliana WRKY1 Protein , Nucleic Acid Research , 2007 , 35 (4): 1145-1154
11. Shifeng Zhu, Mao Chen, Yi Li. , Interaction of the P2 protein of rice dwarf Phytoreovirus with ent-kaurene oxidase resulting in reducing GA content and this may further cause dwarf in RDV infected rice plants , Plant Physiology , 2005 , 139:1935-1945
12. Leister T., Dahlbeck D., Day, D., Li, Y., Staskwicz, B. , Molecular genetic evidence for the role of SGT1 in the intramolecular complementation of Bs2 protein activity in Nicotiana benthamiana , The Plant Cell , 2005 , 17:1268－1278
13. Xuesong Cao, Peng Zhou, Xiaoming Zhang, Shifeng Zhu, Xuehua Zhong, Qi Xiao, Biao Ding, Li Yi. , A RNA silencing suppressor from rice phytoreovirus , Journal of Virology , 2005 , 79:13018-13027 , Highlighted in the issue
14. Li Y, Bao Y, Wei C, et al, , Rice dwarf phytoreovirus segment S6-encoded nonstructural protein has a cell-to-cell movement function , Journal of Virology , 2004 , 78: 5382-5380.
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