本实验室主要兴趣在于：
非孟德尔遗传的生物学意义
非孟德尔遗传的分子机理
植物生殖的细胞分子生物学
非孟德尔遗传指线粒体和质体基因组的遗传。人们都知道真核生命的这些细胞质基因组通常呈现单亲遗传。为什么要单亲遗传？为什么细胞核和细胞质中的遗传物质以不同的方式传递给子代？非孟德尔遗传对真核生命的形成和进化有怎样的作用和意义？本研究组利用不同的实验模式研究这些生命的基本问题。
非孟德尔遗传现象发现于近100年前，但至今分子调控机制不详。常规的理化诱变方法未能在模式动植物中获得相关的突变体，说明其分子调控机制的复杂性。本研究组在完成相关细胞学机理评估的基础上，正在尝试从蛋白质组学的角度探索非孟德尔遗传的基因分子生物学调控机理。
植物的有性生殖是一个复杂的生命活动过程，与非孟德尔遗传有着密切的关联。本研究组同时对被子植物有性生殖过程中的细胞分化、受精等重要的生命活动过程进行研究。
Research Description:
We are interested in the origin, biological significance, and molecular mechanisms of non-Mendelian genetics.
Non-Mendelian genetics refers to the inheritance of the mitochondrial and plastid genomes. It is widely held that these genomes are transmitted in eukaryotes through a uniparental (maternal) lineage. However, it is not clear why the transmission should be uniparental. Why must the genes in a cell be inherited in different ways (i.e., in a Mendelian manner for nuclear genes and a non-Mendelian manner for cytoplasmic genes)? How does non-Mendelian genetics contribute to the origin and evolution of eukaryotes? Our group is attempting to answer these fundamental questions using various experimental models.
Although non-Mendelian genetics were first discovered nearly 100 years ago, the molecular regulation for this phenomenon is unclear. Chemical and physical mutagenesis has not yielded any genetic mutations in model plants, implying that the regulatory mechanism is complex. We are trying to reveal the molecular background using recently developed techniques, such as proteomics.
The sexual reproduction of plants is a complicated procedure that is closely related to non-Mendelian genetics. Our group also focuses on the events of cell differentiation and fertilization in sexual plant reproduction.
代表性论文
1. Zhang D, Kato Y, Zhang LG, Fujimoto M, Tsutsumi N, Sodmergen, Sakamoto W , The FtsH protease heterocomplex in Arabidopsis: dispensability of type-B protease activity for proper chloroplast development , Plant Cell , 2010 , 22: 3710-3725
2. Wang DY, Zhang Q, Liu Y, Lin ZF, Zhang SX, Sun MX, Sodmergen , The levels of male gametic mitochondrial DNA are highly regulated in angiosperms with regard to mitochondrial inheritance , Plant Cell , 2010 , 22: 2402-2416
3. Zhang Q, Sodmergen , Why does biparental plastid inheritance revive in angiosperms , J Plant Res , 2010 , 123: 201-206
4. Hu YC, Zhang Q, Rao GY, Sodmergen , Occurrence of plastids in the sperm cells of Caprifoliaceae: biparental plastid inheritance in angiosperms is unilaterally derived from maternal inheritance , Plant Cell Physiol , 2008 , 49: 958-968
5. Hu YF, Zhang Q, Sodmergen , Potential cytoplasmic inheritance in Wisteria sinensis and Robinia pseudoacacia (Leguminosae) , Plant Cell Physiol , 2005 , 46: 1029 -1035
6. Liu Y, Cui H, Zhang Q Sodmergen , Divergent potentials for cytoplasmic inheritance within the genus Syringa: a new trait associated with speciogenesis , Plant Physiol , 2004 , 136: 2762-2770
7. Liu Y, Zhang Q, Hu YF, Sodmergen , Heterogeneous pollen in Chlorophytum comosum, a species with a unique mode of plastid inheritance intermediate between the maternal and biparental modes , Plant Physiol , 2004 , 135: 193-200
8. Zhang Q, Liu Y, Sodmergen , Examination of the cytoplasmic DNA in male reproductive cells to determine the potential for cytoplasmic inheritance in 295 angiosperm species , Plant Cell Physiol , 2003 , 44: 941-951
9. Sodmergen, Zhang Q, Zhang YT, Sakamoto W, Kuroiwa T , Reduction in amounts of mitochondrial DNA in the sperm cells as a mechanism for maternal inheritance in Hordeum vulgare , Planta , 2002 , 216: 235-244
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