科研领域描述
My laboratory is interested in synapse wiring patterns in the diseased brain (particularly interested in Alzheimer’s disease-AD and Autism Spectrum Disorders-ASDs). The wiring of synapses (including formation, maturation and elimination of synapses) is an active process during not only early development, but also throughout adulthood. Our previous work revealed that deficits in mono-synaptic wiring contribute to the pathological development of AD and ASDs. Now we are studying synaptic wiring diagrams at circuit-level by adopting a combination of molecular/biochemical, genetic, electrophysiological and optogenetic methods. Our aim is to help understand the spatial-temporal properties of neural circuits under physiological and pathological conditions, thus to provide the neural basis for better treatments of AD and ASDs.
本实验室研究病理情况（主要集中在老年痴呆症-AD，和自闭症-ASDs）下大脑神经突触连接的变化。突触的连接（包括突触的形成，成熟和退化）不论在大脑发育的早期，还是成年时期都是一个非常活跃的过程。我们已有的工作证明两个神经元之间的单突触连接的变化与老年痴呆症和自闭症的病理变化有关。当前本实验室运用分子/生化，遗传学，电生理和光遗传学的手段在神经环路层面研究生理和病理条件下神经网络的变化，从而为老年痴呆症和自闭症的治疗提供神经生物学基础。
代表性论文
1. Zhang C., Atasoy D., Ara? D., Yang X.F., Fucillo M.V., Robison A.J., Ko J., Brunger A.T., Südhof T.C. , Neurexins Physically and Functionally Interact with GABAA α1-receptors , Neuron , 2010 , 66, 403-416
2. Zhang, C., Milunsky, J. M., et al. , A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export , Journal of Neuroscience , 2009 , 29, 10843-10854
3. Zhang, C., Wu, B., Beglopoulos, V., Wines-Samuelson, M., Zhang, D., Dragatsis, I., Südhof, T. C., and Shen, J. , Presenilins are essential for regulating neurotransmitter release , Nature , 2009 , 460, 632-636
4. Wu, B., Wang, Y., Xiong, W., Zheng, L., Fu, C., Bruce, I. C., Zhang, C#, and Zhou, Z#. , Optimization of a multi-channel puffer system for rapid delivery of solutions during patch-clamp experiments , Frontiers in Bioscience , 2005 , 10, 761-767
5. Zhang, C.*, Xiong, W.*, Zheng, H., Wang, L., Lu, B., and Zhou, Z. , Calcium- and dynamin-independent endocytosis in dorsal root ganglion neurons , Neuron , 2004 , 42, 225-236
6. Fan, C.*, Chen, X.*, Zhang, C.*, Wang, L., Duan, K., He, L., Cao, Y., Liu, S., Zhong, M., Ulens, C., et al. , A novel conotoxin from Conus betulinus, kappa-BtX, unique in cysteine pattern and in function as a specific BK channel modulator , J. Biol. Chem , 2003 , 278, 12624-12633
7. Bao, L.*, Jin, S.*, Zhang, C.*, Wang, L., Xu, Z., Zhang, F., Wang, L., Ning, F., Cai, H., Guan, J., et al. , Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion , Neuron , 2003 , 37, 121-133
8. Zhang, C., and Zhou, Z. , Ca2+-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons , Nature Neuroscience , 2002 , 5, 425-430 |
