科研领域描述
1. Cell death in neurodegenerative diseases
神经退行性疾病中的细胞死亡机制研究
2. Alzheimer's disease: amyloid toxicity and metabolism, neuronal polarity and biomarkers
老年性痴呆症中的淀粉样蛋白毒性和代谢，神经元极性和生物标记物研究
3. Cell-cell communication in physiological and stress conditions
在正常和应激条件下的细胞间交流研究
代表性论文
1. Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y*, Wang J-H*, Meijers R* , The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue , Neuron , 2014 , 83: 1-11
2. Sun X, Wu Y, Gu M, Zhang Y* , MiR-342-5p Decreases Ankyrin G Level in Alzheimer’s Disease Transgenic Mouse Models , Cell Reports , 2014 , 6: 264-270
3. Chen Q, Sun X, Zhou X-H, Liu J-H, Wu J, Zhang Y*, Wang J-H* , N-terminal horseshoe conformation of DCC is functionally required for axon guidance and may be shared by other neural receptors , J Cell Sci , 2013 , 126: 186-195
4. Sun X, Wang Y, Zhang J, Tu J, Wang X-J, Su X-D, Wang L, Zhang Y* , Tunneling-nanotube direction determination in neurons and astrocytes , Cell Death Dis , 2012 , 3: e438. DOI: 10.1038/cddis.2012.177
5. Cui J, Wang Y, Dong Q, Wu S, Xiao X, Hu J, Chai Z* and Zhang Y* , Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70 , J Neurosci , 2011 , 31: 16277-16240
6. Wang Y, Cui J, Sun X and Zhang Y* , Tunneling-nanotube development in astrocytes depends on p53 activation , Cell Death Differ , 2011 , 18: 732-742
7. Zhang Y*, Xiong W, Lin X, Ma X and Yu L , Roles of mu-opioid receptor phosphorylation in opioid tolerance and dependence , Neurosci Biobehav Rev , 2009 , 33: 1192-1197
8. Zhang Y* , Microinjection Technique and Protocol to Single Cells , Nat Protocols , 2007 , DOI: 10.1038/nprot.2007.487
9. Zhang Y, Beitel L, Goodyer C, Trifiro M and LeBlanc A* , Estrogen and androgen protect against intracellular amyloid beta toxicity , J Neurosci , 2004 , 24: 5315-5321.
10. Zhang Y, McLauglin R, Vereker E, Goodyer C and LeBlanc A* , Selectively cytotoxicty of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons , J Cell Biol , 2002 , 156: 519-529.
11. Zhang Y, Goodyer C and LeBlanc A* , Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7 and –8 , J Neurosci , 2000 , 20: 8384-8389.
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