本实验室主要兴趣在于：
细胞核结构与功能 细胞周期调控研究（包括纺锤体装配机理研究，DNA复制起始调控机理研究，核膜装配机理研究等） Ran GTPase 在细胞核物质运输和细胞周期调控中的作用 肿瘤细胞生物学(肿瘤细胞增殖调节和增殖控制)
1，发现Ran GTPase 控制核膜装配(Science, 2000; Current Biology, 2011; Journal of Cell Science, 2012）。
2，发现Ran GTPase 控制纺锤体组装(Journal of Cell Science, 1999)。
3，建立了应用相关蛋白质小球和细胞(包括卵细胞)提取物为材料的非细胞体系核膜重建模式(Current Biology, 2001, 2002; European Journal of Cell Biology,2002）。
4， 发现核膜物质运输相关蛋白importin beta 参与核膜装配(Current Biology, 2002)。
5，发现Ran 调控核孔复合体装配(European Journal of Cell Biology, 2002)。
6，发现RCC1在染色体上定位所产生的Ran-GTP梯度是纺锤体正确装配所需要的(Current Biology, 2002)。
7，发现Ran GTPase 通过调控核膜物质运输进而调控DNA 复制(Journal of Cell Science,1998)。
8，以实验证明细胞核纤层(Nuclear lamina)对细胞核结构的维持和DNA 复制起重要调控作用(Journal of Cell Science,1996)。
9，发现Nucleoplasin在非洲爪蟾卵提取物细胞凋亡过程中调控染色质的凝集(PNAS， 2005)。
10，发现Aurora A/B, Plk1, Cdk1等激酶综合调控纺锤体装配(PNAS，2009；Cell Research, 2008, 2011; Journal of Cell Science, 2009, 2013a, 2013b)。
代表性论文
1. Wenxiang Fu, Hao Chen, Gang Wang, Jia Luo, Zhaoxuan Deng, Guangwei Xin, Nan Xu, Xiao Guo, Jun Lei, Qing Jiang,and Chuanmao Zhang* , Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly , Proc. Natl. Acad. Sci. USA (PNAS) , 2013 , 110(38): 15295-15300
2. Gang Wang, Qiang Chen, Xiaoyan Zhang, Boyan Zhang, Xiaolong Zhuo, Junjun Liu, Qing Jiang and Chuanmao Zhang* , PCM1 Recruits Plk1 to Pericentriolar Matrix to Promote Primary Cilia Disassembly before Mitotic Entry , Journal of Cell Science , 2013 , 126::1355-1365
3. Zhige Wu, Qing Jiang, Paul R. Clarke* and Chuanmao Zhang* , Phosphorylation of Crm1 by CDK1-cyclin B promotes Ran-dependent mitotic spindle assembly , Journal of Cell Science , 2013 , 126, 3417-3428
4. Quanlong Lu, Zhigang Lu, Qinying Liu, Li Guo, He Ren1, Jingyan Fu, Qing Jiang, Paul R Clarke, Chuanmao Zhang* , Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembly via importin-alpha/beta , Cell Research , 2012 , 22:1562-1575
5. Shijiao Huang and Chuanmao Zhang* , The Coordination between DNA Replication Initiation and Other Cell Cycle Events , In Book: DNA Replication-Current Advances , 2011 , p233-252
6. Wenxiang Fu, Qing Jiang and Chuanmao Zhang* , Novel functions of endocytic player clathrin in mitosis , Cell Research , 2011 , 21: 1655-1661
7. Qinying Liu, Jingying Yu, Xiaolong Zhuo, Qing Jiang and Chuanmao Zhang* , Pericentrin contains five NESs and an NLS essential for its nucleocytoplasmic trafficking during the cell cycle , Cell Research , 2010 , 20:948
8. Wenxiang Fu, Wei Tao, Puwei Zheng, Jingyan Fu, Minglei Bian, Qing Jiang, Paul R Clarke and Chuanmao Zhang , Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment , Journal of Cell Science , 2010 , 123: 3645-3651
9. Xuelong Lu, Yang Shi, Quanlong Lu, Yan Ma, Jia Luo, Qingsong Wang, Jianguo Ji, Qing Jiang and Chuanmao Zhang* , Requirement for lamin B receptor and its regulation by importin , J Biol Chem , 2010 , 285: 33281
10. Xiaoyan Zhang, Qiang Chen, Jia Feng, Junjie Hou, Fuquan Yang, Junjun Liu, Qing Jiang and Chuanmao Zhang* , Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the centrosome , Journal of Cell Science , 2009 , 122: 2240-2251
11. Fei Lu, Rongfeng Lan, Hongyin Zhang, Qing Jiang, and Chuanmao Zhang* , Geminin is partially localized to centrosome and plays a role in proper centrosome duplication , Biology of the Cell , 2009 , 101: 273
12. Jingyan Fu, Minglei Bian, Junjun Liu, Qing Jiang, and Chuanmao Zhang* , A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function , Proc. Natl. Acad. Sci. USA (PNAS) , 2009 , 106 (17): 6939
13. Clarke PR and Zhang CM , Spatial and temporal coordination of mitosis by Ran GTPase , Nature Review Molecular Cell Biology , 2008 , 9: 467-477
14. Qiang Chen, Xiaoyan Zhang, Qing Jiang, Paul Clarke, and Chuanmao Zhang* , Cyclin B1 is localized to unattached kinetochores and is required for chromosome alignment during mitosi , Cell Research , 2008 , 18: 268-280
15. Yan Ma, Shang Cai, Quanlong Lu, Xuelong Lu, Qing Jiang, Jun Zhou and Chuanmao Zhang* , Inhibition of Deacetylation Impairs Microtubule-kinetochore Attachment through Interfering with Kinetochore Integrity, Centromere Function and Microtubule Behavior , Cellular and Molecular Life Sciences , 2008 , 65
16. Jingyan Fu，Minglei Bian，Qing Jiang and Chuanmao Zhang , Roles of Aurora Kinases in Mitosis and Tumorigenesis , Molecular Cancer Research , 2007 , 5(1): 1-10
17. Yan Ma, Shang Cai, Quanlong Lv, Xuelong Lv, Quan Zhang, Qing Jiang, Sodmergen，Zhonghe Zhai and Chuanmao Zhang , Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin β , Journal of Cell Science , 2007 , 120: 520-530
18. Zhigang Lu, Chuanmao Zhang*, and Zhonghe Zhai* , Nucleoplasmin regulates chromatin condensation during apoptosis. , Proc. Natl. Acad. Sci. USA (PNAS) , 2005 , 102: 2778-2783 , (Co-corresponding author)
19. Hui Ren, Liya Wang, Matthew Bennett, Yuhe Liang, Xiaofeng Zheng, Fei Lu, Lanfen Li, Jie Nan, Ming Luo, Staffan Eriksson, Chuanmao Zhang, and Xiao-Dong Su , The Crystal Structure of human Adenylate Kinase 6: An Adenylate Kinase Localized to the Cell Nucleus. , Proc. Natl. Acad. Sci. USA (PNAS) , 2005 , 102:303-308.
20. Lu, Z, Zhang C* and Zhai. Z*. , LDFF, the large molecular weight DNA fragmentation factor, is responsible for the large molecular weight DNA degradation during apoptosis in Xenopus egg extracts , Cell Research , 2004 , 14: 134-140 , (Co-corresponding author)
21. Moore, WJ. Zhang, C. and PR. Clarke , Targeting of RCC1 to Chromosomes Is Required for Proper Mitotic Spindle Assembly in Human Cells. , Current Biology. , 2002 , 12：1442-1447.
22. Zhang, C., Hutchins, JR, Mulhausser, P, Kutay, U., and Clarke, P. R. , Role of importin β in the control of nuclear envelope assembly by Ran. , Current Biology. , 2002 , 12: 498-502.
23. . Zhang C., Goldberg, MW, Moore WJ, Allen, TD, Clarke, PR. , Concentration of Ran on chromatin induces decondensation, nuclear envelope formation and nuclear pore complex assembly. , European Journal of Cell Biology , 2002 , 81, 623-633.
24. Clarke, P.R., and Zhang, C. , Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? , Trends Cell Biol. , 2001 , 11：366-371.
25. Zhang, C*., and Clarke, P. R*. , Chromatin-independent Nuclear Envelope Assembly induced by Ran GTPase in Xenopus Egg Extracts. , Science. , 2000 , 288:1429-1432.
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