主要研究领域包括病毒和宿主的识别、植物激素受体以及人类重要免疫受体和配体的识别,利用重组DNA技术,在结构生物学、蛋白质化学等方面,探究这些重要蛋白质相互作用的分子基础和作用机理。
代表性论文
1. Shan S and Chen X , Crystallization and preliminary X-ray analysis of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosis , Acta Cryst Section F , 2011 , F67, 821-823 , correspondence auther
2. Shan S, Chen X, Liu T, Zhao H, Rao Z and Lou Z , Crystal structure of 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE) from Mycobacterium tuberculosi , FASEB J , 2011 , 1577-84 , co-first auther
3. Chen, X and Springer, T, et al. , Structural Plasticity in IgSF Domain 4 of ICAM-1 Mediates Cell Surface Dimerization , PNAS , 2007 , 104, 15358-15363
4. Bell SG, Chen X, Rao, Z. et al , Engineering substrate recognition in catalysis by cytochrome P450cam , Biochem Soc Trans , 2003 , 31(3):558-562
5. Chen, X., Rao, Z. et al , Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene , J Biol Chem , 2002 , 277, pp. 37519-37526