科研项目 1、青少年阶段社会隔离干扰中脑多巴胺系统神经发育并诱发成年大鼠认知障碍的分子机制研究, 国家自然科学面上基金, 35万, 2011.1-2013.12, 主持 2、早期隔离应激诱导的拟精神分裂症颠倒学习障碍的神经生物学机制研究,国家自然科学面上基金,25万,2007年1-2009年12,主持 3、抑郁症和精神分裂症的基因与环境相互作用机理研究 - 疾病的脑高级功能障碍(子课题), “国家重点基础研究发展计划资助(973)”及课题编号2007CB512306, 2007-2012 4、拟精神分裂症动物模型的深入化研究,国家自然科学青年基金,18万,2002年1-2005年12,主持 5、情绪过程、神经生理机制与教育干预,教育部科学技术重点项目,1.5万,2002-2005,参与
研究兴趣: 1 ,拟精神分裂症动物模型的认知障碍及其中枢机制研究 2 ,心理神经免疫学研究
英文论著 Li, M., Xue, X., Shao, S., Shao, F*., & Wang, W. (2013). Cognitive, emotional and neurochemical effects of repeated maternal separation in adolescent rats. Brain Research, 1518, 82-90. (corresponding author) Xue, X., Shao, S., Li, M., Shao, F*., & Wang, W. (2013). Maternal separaton induces alterations of serotonergic system in different aged rats. Brain Research Bulletin, 95, 15-20. (corresponding author) Shao, F., Han, X., Shao, S., & Wang W. (2013). Adolescent social isolation influcences cognitive function in adult rats. Neural Regeneration Research, 8(11), 1025-1030. Xue, X., Shao, S., Wang, W., & Shao, F*. (2013). Maternal separation induces alterations in reversal learning and brain-derived neurotrophic factior expression in adult rats. Neuropsychobiology, 68, 243-249.(corresponding author) Han, X., Li, N., Xue, X., Shao, F*., & Wang, W. (2012). Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats. Brain Research, 1447(0), 38-43. (corresponding author) Han, X., Wang, W., Shao, F*., & Li, N. (2011). Isolation rearing alters social behaviors and monoamine neurotransmission in the medial prefrontal cortex and nucleus accumbens of adult rats. Brain Research, 1385, 175-181 (corresponding author) Han, X., Li, N., Meng, Q., Shao F*., Wang, W (2011). Maternal immune activation impairs reversal learning and increases serum TNF-α in offspring. Neuropsychobiology, 64, 9-14 (corresponding author) Meng, Q., Li, N., Han, X., Shao, F*., & Wang, W. (2011). Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain. European Journal of Pharmacology,650, 229-232 (corresponding author) Han, X., Wang, W., Xue X., Shao, F*., & Li, N. (2011). Brief social isolation in early adolescence affects reversal learning and forebrain BDNF expression in adult rats. Brain Research Bulletin,86,173-178 (corresponding author) Luo,X, Shao, F.,Guan, X., Xie X., Wang, WW. Progress in the “brain-derived neurotrophic factor depression hypothesis”. Neural Regeneration Research, 2010,5(23): 1817-1824 Shao, F., Han, X., Li, N., & Wang, W. (2010). Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult rats.. European Journal of Pharmacology, 649(1-3), 202-205. Meng, Q., Li, N., Han, X., Shao, F., & Wang, W. (2010). Peri-adolescence isolation rearing alters social behavior and nociception in rats. Neuroscience Letters, 480(1), 25-29. (corresponding author) Shao F, Jin J, Meng QX, Liu M, Xie X, Lin WJ, Wang WW (2009). Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats. Physiol Behav, 98: 251-257 Jihuan Chen, Wenjuan Lin, Weiwen Wang, Feng Shao (2004). Enhancement of antibody production and expression of c-fos in the insular cortex in response to a conditioned stimulus after a single-trial learning paradigm. Behavioural Brain Research, 154: 557-565 Shao Feng, Lin Wenjuan, Wang Weiwen. (2003). The effect of emotional stress on the primary humoral immunity of rats. J of psychopharmacology, 17(2):153-157 Li Liang Shao Feng (2003). Impaired auditory sensorimotor gating: An animal model of schizophrenia. Chinese Science Bulletin, 48(19):2031-2037 Lin Wenjuan Wang Weiwen Shao Feng (2003). New animal model of emotional stress: Behavioral, neuroendocrien and immunological consequences. Chinese Science Bulletin, 48(15): 1565-1568
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