李中军：药物化学博士，教授，博士生导师；北京大学药学院化学生物学系 主任
1982~1987年就读于北京医科大学药学院化学专业获理学学士学位，1987-1992年就读于北京医科大学药学院药物化学专业获药物化学博士学位，后留校任教从事教学和科研工作。1999年被聘为教授，2001年被聘为博士生导师。从1994年起，先后获得了国家自然科学基金重大专项、重点课题、面上项目、科技部“973”、科技部创新药物重大专项、国家新药研究基金、卫生部科研基金、教育部创新团队等三十项基金的支持。长期以来从事糖化学、糖化学生物学及相关创新药物的研究。已发表学术论文100余篇和专著一部，申报中国专利15项，已获授权8项。担任Chinese Chemical Letter、化学通报、中国药学（英）编委。已指导研究生60余人获得学位。曾获国家教委科技进步三等奖及中国药学会-Servier青年药物化学奖。目前承担的课程有“有机合成”(药学院本科)、糖化学(药学院研究生)。先后获得医学部首届最受学生欢迎“十佳教师”、研究生“良师益友”及“我身边的好老师”等称号。
研究方向与兴趣：
寡糖合成方法学及快速组装策略研究
基于糖类的选择性合成研究
糖化学生物学研究
创新药物研究
代表性论文和专著：
1. Yunfeng Li, Yao Meng, Xiangbao Meng, Zhongjun Li, Stereoselective synthesis of polyoxygenated linear diaza-triquinanes via intramolecular 1,3-dipolar cycloaddition of sugar-derived hex-5-enals, Tetrahedron, 2011, 67, 4002.
2. Zhao-Jun Yin, Bo Wang, Yang-Bing Li, Xiang-Bao Meng, Zhong-Jun Li, A Highly Efficient and Mild Method for Regioselective de-O-benzylation of Saccharides by Co2(CO)8-Et3SiH- CO Reagent System, Organic Letters, 2010, 12, 536.
3. Min Yu, Yang Yang, Rongcheng Han, Qiang Zheng, Lijun Wang, Yuankai Hong, Zhongjun Li, Yinlin Sha, Polyvalent Lactose-Quantum Dot Conjugate for Fluorescent Labeling of Live Leukocytes, Langmuir, 2010, 26, 8534.
4. Yang Yang, Min Yu, Tingting Yan, Zhihui Zhao, Yinlin Sha, Zhongjun Li, Characterization of multivalent lactose quantum dots and its application in carbohydrate-protein interactions study and cell imaging, Bioorganic & Medicinal Chemistry, 2010, 18, 5234.
5. Yang Yang, Yuetao Zhao, Tingting Yan, Min Yu, Yinlin Sha, Zhihui Zhao, Zhongjun Li, Design and fabrication of multivalent gal-containing quantum dots and study of its interactions with a sialo-glycoprotein receptor (ASGP-R), Tetrahedron Letters, 2010, 51, 4182.
6. Gui-Hui Chen, Pan Pan, Ying Chen, Xiang-Bao Meng, Zhong-Jun Li, Selective deprotection of the Cbz amine protecting group for the facile synthesis of kanamycin A dimers linked at N-3′′ position, Tetrahedron, 2009, 65, 5922.
7. Dong Han, Xiang-Bao Meng, Lin-Na Wang, Hong Liu, Yun Yao, Zhuo Wang, Zhen-Jun Yang, Zhongjun Li, Efficient synthesis of a series of novel fructose-based 3-acetyl-5-alkyl-2,3- dihydro-1,3,4-oxadiazole derivatives and studies of the reaction mechanism, Tetrahedron: Asymmestry., 2009, 20, 399.
8. Zhihui Zhao,Qing Li, Jiale Hu, Zhongjun Li, Jinghua Liu, Aihua liu,Peng Deng, Lin Zhang,Xiaowei Gong, Kesen Zhao, Shuangquan Zhang, Yong Jiang, Lactosyl derivatives function in a rat model of severe burn shock by acting as antagonists against CD11b of integrin on leukocytes, Glycoconj. J., 2009, 26, 173.
9. Min Li, Wan Sun, Ya-ping Yang, Bo Xu, Wen-yuan Yi, Yan-xia Ma, Zhong-jun Li, Jing-rong Cui, In vitro anticancer property of a novel thalidomide analogue through inhibition of NF-kB activation in HL-60 cells. Acta Pharmacol. Sin., 2009, 30, 1.
10. Gui-Hui Chen, Pan Pan, Yun Yao, Ying Chen, Xiang-Bao Meng, Zhong-Jun Li, Regio- selective Modification of Amino Groups in Aminoglycosides Based on Cyclic Carbamate Formation, Tetrahedron, 2008, 64, 9087.
11. He-Qing Huang, Zhi-Hui Qin, Sheng-Li Cao, Huai-Yu Li, Meng-Shen Cai, Zhong-Jun Li, You-En Shi, Synthesis and bioactivities of two Multiple Antigen Peptides in relation to Schistosoma, Bioorg. Med. Chem. Lett., 2005, 15, 2415.
12. 蔡孟深，李中军主编，“糖化学”，化学工业出版社，北京，2007.
|
