期刊缩写       METAB ENG

期刊全称       METABOLIC ENGINEERING 代谢工程

期刊ISSN      1096-7176

2012-2013最新影响因子     6.859

期刊官方网站       http://www.journals.elsevier.com/metabolic-engineering/

期刊投稿网址       http://ees.elsevier.com/mbe/

通讯方式       ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, USA, CA, 92101-4495

涉及的研究方向    工程技术-生物工程与应用微生物

出版国家       UNITED STATES

出版周期       Quarterly

出版年份       1999

年文章数       72

 

 

Metabolic Engineering

An official journal of the International Metabolic Engineering Society

Impact Factor (2012): 6.859

 

Aims and Scope:

Metabolic Engineering (MBE) is devoted to the publication of original research papers on the directed modulation of metabolic pathways for metabolite over production or the improvement of cellular properties. Papers describing native pathway engineering and synthesis of heterologous pathways for converting microorganisms into microbial cell factories are also welcome.

 

Experimental, computational, and modelling approaches for the elucidation of metabolic pathways and their manipulation by genetic, media, or other environmental means are presented. Efficient probing of metabolic pathways requires the application of appropriate methods from molecular biology and biochemistry, along with modeling and data analysis techniques from engineering. MBE provides a forum for communicating such interdisciplinary research, as well as relevant results in the constituent areas of biochemistry, molecular biology, applied microbiology, cellular physiology, cellular nutrition in health and disease, and biochemical engineering.

 

Types of papers:Original Research Papers, Review Papers.

 

Metabolic engineering is a new field with applications in the production of chemicals, fuels, materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the synthesis of molecular biology techniques and the tools of mathematical analysis, which allow rational selection of targets for genetic modification through measurements and control of metabolic fluxes.

 

The objective is to identify specific genetics or environmental manipulations that result in improvements in yield and productivities of biotechnological processes. Key features of the book are pathway integration and the focus on metabolic flux as a fundamental determinant of cell physiology. The book keeps mathematical complexity to a minimum, and provides a glossary of biological terms to facilitate use of the book by a broader spectrum of readers. A web page exists to communicate updates of the codes and homework problems.

 

It demonstrates metabolic engineering in action with numerous examples of pathway modification. It includes methods for identifying key enzymes in metabolic networks. It contains a comprehensive review of metabolic biochemistry. It discusses metabolic regulation at the gene, enzyme, operon, and cell levels. It explains concepts of stoichiometry, kinetics, and thermodynamics of metabolic pathways. It minimizes mathematical complexity. It features links to a Web page to communicate updates of the software code and homework problems.

 

 

Editor-in-Chief

Greg Stephanopoulos

Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

 

Associate Editors

Vassily Hatzimanikatis

école Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

 

Joanne Kelleher

Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

 

Sang Yup Lee

Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea

 

James Liao

University of California at Los Angeles, Los Angeles, California, USA

 

Costas Maranas

Pennsylvania State University, University Park, Pennsylvania, USA

 

Jens Nielsen

Chalmers University of Technology, G?teborg, Sweden