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INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY杂志杂环化学期刊论文发表 |
| ABSTRACT: 6-substituted/unsubstituted-2-cholro-3-formylquinolines 1(a, b) were synthesized by Vilsemeier-Haack reaction. These compounds on microwave irradiation with 4M HCl yielded 6-substituted/unsubstituted-2-hydroxy quinoline-3-carbaldehydes 2(a, b). These resulting compounds on treatment with different substituted hydrazides yielded the Schiff bases 3(a-j). The structure of all newly synthesized compounds was confirmed by spectral study such as IR, and 1H NMR spectroscopy. All the synthesized compounds were screened for antibacterial and antitubercular activities. For antibacterial activity MIC values for the synthesized compounds were determined using serial dilution method and ciprofloxacin and norfloxacin were used as standard drugs and for antitubercular activity the synthesized compounds were screened against Mycobacterium tuberculosis strain H37Rv using the Microplate Alamar Blue assay (MABA) method using isoniazid as the standard drug. Compounds 3a, 3c, 3e, 3g and 3j showed significant antibacterial activity and compounds 3c, 3g and 3j showed good antitubercular activity. |
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