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Materials and Methods:
Subjects: 
In this study 662 cases of patients who diagnosed as schizophrenia from all in-patients in the chronic psychiatric health care department of Yuliyongmin hospital were chose as the sample for statistical analysis. All cases participating in this study has been fully explained by the researcher, and contented to join in this research.
Materials:
The research implementing term was from April 10th to 24th in the year of 2000, during which all the selected patients were phlebotomized in batch and the blood samples were collected and sent to the checking department in Yuliyongmin hospital, and HBsAg was tested using monoclonal ELISA –HBs method, and GOT, Alk-P and r-G biochemical values were tested using the same examining materials.

Data Statistical Analysis Methods:
In this study SPSS software was used to do data analysis, including Description Analysis, Chi-Square Test and Fisher’s Exact Test, and comparing analysis using hypothesis test method.
Results:
1. Basic information:

The total cases enlisted in this study were 662, all of which were patients diagnosed as schizophrenia hospitalized longer than one year in Yuliyongmin hospital. Male patients had 390 and female 272, and their ages ranged from 20 to 83 years old with the mean age as 42.54 (42.54±10.67) year. Following table 1 shows their distribution status.

Table 1. Age and sex distribution of the in-patients in the chronic psychiatric health care department of Yuliyongmin hospital.

2. The results of HBsAg checking was showed in the following table 2, and taking table 3 showed age and sex distribution of the whole population in Taiwan as the baseline, the age and sex balanced total prevalence rate was 9.19%, in which for male was 12.20% and for female was 6.09%, which had significant difference checked by hypothesis test (p<0.05).

Table 2. HBsAg carrier rate of the in-patients in the chronic psychiatric health care department of Yuliyongmin hospital.

Table 3. Distribution of whole population in Taiwan in 1989.

3. Overall vaccination program had been promoted by health administrating office from 1984 in Taiwan area. The vaccination was begun from free of charge vaccination for new born babies, gradually opened to other age-segment people. All citizens with HBsAg negative in their serum can voluntarily accept the vaccination in order to reduce the risk of hepatitis B infection among the people (10, 11). By reason of this, the prevalence rate of hepatitis B in recent years had changed somewhat,  so taking newest hepatitis B prevalence rate study as control study was necessary, which was the reason for using the community study in Ziguan region of Gaoxiong county in the year 2000 (12)  showed in table 4 as the control study in this research.

Because the samples in that community study were populations above 45 years old, so in this study we also only chose patients above 45 years old in total samples, which were showed as table 5. Based on the age and sex population distribution in 2000, compare was made after age and sex balanced for each group data. After age and sex balanced and checked by the hypothesis test, the prevalence rate of HBsAg carrier in long term hospitalized schizophrenia patients was 12.92%. In the community study in Ziguan region of Gaoxiong county, the prevalence rate between male and female had no significant difference, however, significant difference existed in this study (p<0.05). For comparing the prevalence rate of each sex in the two studies, no significant difference existed for male prevalence rate (which is 11.10% in this study while 13.98% in Ziguan region study), and the chief difference consist in the prevalence rate of female as 4.55% in this study, which was significantly lower than that of Ziguan region study, which was 11.82%.
 
Table 4. HBsAg carrier rate in community of Ziguan region in Gaoxiong county
 
Table 5. HBsAg carrier rate for selected long term hospitalized patients above 45 years old fitting the Ziguan region study.

The document was translated by the Chinese translator of Huayiwang Chinese Translation company in Beijing.
材料与方法

研究对象
本研究从玉里荣民医院所有慢性精神科健保病床之住院患者选取其中诊断为精神分裂症之病人共计662位作为统计分析之样本，所有参与本研究的个案皆经研究者的说明，并同意加入。
研究工具
实施日期自民国八十九年四月十日至四月二十四日之间，分批进行全面性抽血，搜集后之检体送交玉里荣民医院检验室，以酵素免疫分析法( Monoclonal ELISA -HBs )检验B型肝炎表面抗原( HBsAg )，并以同样的检体做GOT、Alk-P及r-GT之生化值检测。
资料统计分析方法
本研究使用SPSS软件进行资料分析，包括描述性分析、Chi-Square Test和Fisher’s Exact Test，以及使用Hypothesis test做比对分析。 

结果
一．基本资料　　　　　　　　　　　　　　　　　　　　　　　　　　　　　  参与本研究个案总数共有662位，其皆为在玉里荣民医院住院超过一年以上之诊断为精神分裂症患者。其中男性为390位、女性为272位，年龄范围分布在20-83岁，平均年龄为42.54 (42.54±10.67) 岁。其分布情况如下表一。
表一　玉里荣民医院慢性精神科健保病床住院患者之年龄性别分布

二．经检验B型肝炎表面抗原( HBsAg )后，其结果如下表二所示，以八十九年全国人口年龄性别分布做基准如下表三，经年龄性别标准化后总盛行率为9.19%，男性盛行为12.20%，女性盛行率为6.09%，以Hypothesis test检定呈现有意义的差异(p<0.05)。

表二　玉里荣民医院慢性精神科健保病床住院患者之B型肝炎表面抗原带原率
表三　８９年全国人口分布状况 

三．台湾地区自1984年开始，卫生主管机关推动全面性的疫苗接种计划，由新生儿免费接种开始，逐步开放到其它的年龄层，凡是血清HBsAs阴性的国民，皆可自愿接种，以期减少民众受到B型肝炎的感染（10. 11.），故近年来B型肝炎盛行率已出现变化，因此必须要以最新的B型肝炎盛行率研究做为对照组研究，故此次以民国八十六年所做之高雄县梓官乡之社区研究 （12）如表四做为对照组做比对。

因该研究选取45岁以上之民众做为样本，故只选择本研究样本中45岁以上之病患如表五，并以八十九年全国人口年龄性别分布做基准，各做年龄性别标准化后再进行比对。其经年龄性别标准化后并以Hypothesis test检定，长期住院之精神分裂症患者其B型肝炎带原盛行率为7.83%，有意义地低于高雄县梓官乡社区研究的盛行率12.92%，并且高雄县梓官乡社区研究中，男女性盛行率并没有有意义地差异，而本研究中则存在有有意义地差异(p<0.05)。且比对两研究中性别盛行率的差异，其中男性盛行率并没有意义之差异（本研究为11.10%，梓官乡研究为13.98%），主要差异在于本研究之女性盛行率为4.55%，有意义地远低于梓官乡研究之11.82%。

表四　高雄县梓官乡社区之B型肝炎表面抗原带原率 
表五　配合梓官乡研究选取45岁以上长期住院患者之B型肝炎表面抗原带原率

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