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Huayiwang Chinese Translation Sample in 2002 in the field of health care

Study on Hepatitis B and abnormal Liver function of In-patients in Chronic Psychiatric Department
Prevention of hepatitis B is an important item to maintain health for the in-patients in chronic psychiatric department for their particularity and the influence of their long term team living, so in this study we chose 662 case patients with diagnosed as schizophrenia from all in-patients in the chronic psychiatric health care department of Yuliyongmin hospital as the sample for statistical analysis. All of them were phlebotomized to detect Hepatitis B surface antigen (HBsAg) and other blood biochemical values including GOT and γ-GT etc., and the data were statistical analyzed with SPSS software, to understand the difference between long hospitalized psychiatric department patients and common people. The influence of HBsAg on liver function and its comparison with other factors affecting liver function were further investigated. The results showed that the age and sex balanced prevalence rate of HBsAg was 9.19%, and for male it was 9.73%, which was higher than female’s 6.09%. Moreover, this rate is significantly lower than that in a community research in Ziguan area of Gaoxiong county which was 12.92%, and the main difference existed in the female prevalence rate of 4.55% of this research which is significantly lower than 11.82% of the research in Ziguan area. The result of an Indian study made before showed that the HBsAg prevalence rate of schizophrenia in-patients was 11%, far higher than 2% of control group, which was reverse from our study outcome. Further investigate on the relation between abnormal GPT value and HBsAg positive showed that no meaningful correlation existed, however, significant correlation showed between abnormal GPT value and abnormal γ-GT value, in which only the abnormal GPT value of male patients significantly correlated with γ-GT abnormal value, others all showed no meaningful correlation.

Keywords: Hepatitis B Surface Antigen (HBsAg), Prevalence rate, GPT, γ-GT, Alk-P
 
Introduction:
 
Hepatitis B virus is the main cause of the prevailing of chronic liver diseases such as hepatocellular carcinoma and hepatocirrhosis etc. in Taiwan area, which has been confirmed from suspicion in shortly more than ten years (1, 2, 3). Almost every one in Taiwan area had been infected by hepatitis B virus. Although most of them have recovered and become anti-HBs or anti-HBe carrier, the HBsAg positive carrier rate is still very high as about 15% to 20% (4, 5, 6, 7, 8). The HBsAg carrier is not only the communicating reservoir of hepatitis B, but also has more high danger rate to form chronic liver diseases such as hepatocellular carcinoma and hepatocirrhosis etc. in the future than no HBsAg carrying person. So the prevention and treatment of hepatitis B virus infection is one of the most important public health works in Taiwan area, moreover, sufficiently understanding of the infection rate in different groups of people and the transforming of the carrier state is the first step for the hepatitis B prevention and treatment works.
 
Because hepatitis B acts as a very important role in the health endangering aspect for our people, adding that the particularity of the in-patients in chronic psychiatric department including the violence action tendency when their symptoms are instable and frequently injection treatment needing, and the influence of the long term team living, all of which might augment the risk of contracting hepatitis B, and the result of an investigate made before in India showed that the prevalence rate (11%) of HBsAg for the in-patients with schizophrenia is very much higher than that of control group (2%), so, similar study in our area is very urgent, since the carrying of hepatitis B can possibly lead to abnormal liver function.
 
So the aim of this study is to firstly understand the prevalence rate of hepatitis B carrier in in-patients with schizophrenia in this area, and further compare it with that of common population in our region in order to see if there is any difference between them and further comprehend the cause of this difference. After that further study on if it can affect liver function, and probe of true risk factors influence the abnormal liver function, will be done, as reference for further health maintaining in the future.

The following Chinese Transltion document is supply by Huayiwang Mandarin translation company
慢性精神科住院病患之B型肝炎与肝功能异常研究
由于精神科慢性住院病人的特殊性及长期团体生活的影响下，防治B型肝炎是健康维护的重要项目，故本研究从玉里荣民医院所有慢性精神科健保病床之住院患者选取其中诊断为精神分裂症之病人662位作为统计分析之样本进行全面性抽血，检验B型肝炎表面抗原及其它血液生化值包括GOT和γ-GT之检查，采用SPSS软件做统计分析，以了解长期住院之精神科病患与一般人口之差异状况。并进一步研究其B型肝炎带原对肝功能之影响，以及其它因子对肝功能影响做比对。结果显示HBsAg之经年龄性别标准化后盛行率为9.19%，，且男性盛行率9.73%高于女性盛行率6.09%。并且有意义地低于高雄县梓官乡社区研究的盛行率12.92%，其主要差异在于本研究之女性盛行率为4.55%，有意义地远低于梓官乡研究之11.82%。与曾在印度做过之研究的结果显示精神分裂症住院病人之HBsAg盛行率11%远高于对照组2%的结论做比较，与本研究结果相反。进一步探讨GPT值异常与B型肝炎带原之关系并没有有意义地相关，倒是GPT值异常与γ-GT异常呈现有意义地相关，并且只有男性之GPT值异常与γ-GT异常呈现有意义地相关，其它皆无有意义之相关性。
 
关键词：Ｂ型肝炎表面抗原(HBsAg)，盛行率，GPT，γ-GT，Alk-P
前言
B型肝炎病毒是台湾地区肝细胞癌、肝硬化等慢性肝病盛行的主要原因，也在短短的十余年间，由怀疑而得到证实（1. 2. 3.）。台湾地区的人口，几乎全部都曾经感染过B型肝炎病毒，虽然其中的大部分已经复原而带有表面抗体（anti－HBs）、或核心抗体（anti－HBe），但是遗留的表面抗原（HBsAg）阳性带原者比率仍然非常高，大约在15％至20％之间（4. 5. 6. 7. 8.）。带原者不仅是B型肝炎病毒的传染窝薮（reservoir），本身在未来形成肝细胞癌、肝硬化等慢性肝病的危险性，亦比非带原者高出甚多。所以B型肝炎感染的防治，是台湾地区最重要的公共卫生工作之一；而充分掌握各种人口族群的感染率、与带原状态的变迁情形，更是防治工作的首要步骤。
由于B型肝炎在国人的健康危害中扮演非常重要之角色，且因为精神科慢性住院病人的特殊性，包括其因症状不稳定时可能有暴力行为和需接受较频繁之针剂治疗，及长期团体生活的影响下，都可能增加感染B型肝炎之危险性，之前在印度做过之研究的结果显示精神分裂症住院病人之HBsAg盛行率11%远高于对照组2%(9)的结论，更促使本土研究的急切性，因为B型肝炎带原有可能造成肝功能异常。
故本研究目的先了解国内精神分裂症住院病人之B型肝炎带原盛行率，进而与国内一般人口的B型肝炎带原盛行率做比对，以了解其两者间是否有差异，并试图了解其差异之原因。之后再就其对肝功能是否有影响进一步研究，并探讨真正影响肝功能异常之危险因子，以做为未来进一步健康维护之参考。

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